GDC-0084

Base Information

Chemical Name:GDC-0084
CAS No.:1382979-44-3
Molecular Formula:C18H22N8O2
Molecular Weight:382.42
Hs Code.:
Mol file:1382979-44-3.mol

Synonyms:GDC-0084;5-[8,9-Dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-pyrimidinamine

Suppliers and Price of GDC-0084

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Paxalisib(GDC-0084) >98%
1 g
$ 1700.00

DC Chemicals
Paxalisib(GDC-0084) >98%
250 mg
$ 800.00

Crysdot
GDC-0084 98+%
100mg
$ 956.00

Crysdot
GDC-0084 98+%
50mg
$ 574.00

Biosynth Carbosynth
GDC 0084
2 mg
$ 94.00

Biosynth Carbosynth
GDC 0084
1 mg
$ 60.00

Biosynth Carbosynth
GDC 0084
5 mg
$ 172.00

Biosynth Carbosynth
GDC 0084
25 mg
$ 500.00

Biosynth Carbosynth
GDC 0084
10 mg
$ 275.00

ApexBio Technology
GDC-0084
10mg
$ 253.00

Total 22 raw suppliers

Chemical Property of GDC-0084

Chemical Property:

PKA:2.62±0.40(Predicted)
PSA：117.10000
Density:1.60±0.1 g/cm3(Predicted)
LogP:1.61360
Solubility.:insoluble in H2O; insoluble in EtOH; ≥2.83 mg/mL in DMSO with ultrasonic

Purity/Quality:

99%, ^*data from raw suppliers

Paxalisib(GDC-0084) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses GDC-0084 is an inhibitor of phosphoinositide 3-kinase (PI3K) and mTOR (1,2). Inhibitors of PI3K are useful compounds for developing treatments for brain tumors.

Technology Process of GDC-0084

There total 6 articles about GDC-0084 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1382980-58-6
2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

: 1382979-44-3
GDC-0084

Guidance literature:: With potassium phosphate monohydrate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); In tetrahydrofuran; water; at 67 ℃; for 5h; Reagent/catalyst; Temperature; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.6b00011

Reference yield:

: 95758-04-6
2-chloro-6-(morpholin-4-yl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1382979-44-3
GDC-0084

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.42 h / -78 °C

1.2: 2 h / -78 - 0 °C

2.1: toluene-4-sulfonic acid / methanol / 0.5 h / 50 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water; N,N-dimethyl-formamide; 4.1: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.6b00005

Reference yield:

: 1198171-66-2
2-(2-chloro-6-morpholino-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)propan-2-ol

: 1382979-44-3
GDC-0084

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 0.5 h / 50 °C

2: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; toluene-4-sulfonic acid; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.6b00005