2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

Base Information

Chemical Name:2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine
CAS No.:1382980-58-6
Molecular Formula:C₁₄H₁₈ClN₅O₂
Molecular Weight:323.782
Hs Code.:

Synonyms:2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

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Chemical Property of 2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

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Technology Process of 2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

There total 6 articles about 2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198171-62-8
2-(2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol

: 106-93-4
ethylene dibromide

: 1382980-58-6
2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

: C₁₄H₁₈ClN₅O₂

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Reagent/catalyst; Solvent; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.oprd.6b00011

Reference yield:

: 1198171-62-8
2-(2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol

: 106-93-4
ethylene dibromide

: 1382980-58-6
2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

: C₁₄H₁₉BrClN₅O₂

: C₁₄H₁₈ClN₅O₂

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 90 ℃; for 12h; Reagent/catalyst; Solvent; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.oprd.6b00011

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 1382980-58-6
2-chloro-6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purine

: C₁₄H₁₈ClN₅O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / ethyl acetate / 3 h / 20 - 55 °C / Inert atmosphere; Large scale

2.1: methanol / 24 h / 0 - 25 °C / Inert atmosphere; Large scale

3.1: isopropylmagnesium chloride; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -15 - -5 °C / Inert atmosphere; Large scale

3.2: 2 h / -10 °C / Inert atmosphere; Large scale

4.1: hydrogenchloride / water; methanol / 1 h / 50 °C / Inert atmosphere; Large scale

5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; n-butyllithium; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; caesium carbonate; In tetrahydrofuran; methanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.oprd.6b00011