2,4-Dibromo-3-chloropyridine

Base Information

• Chemical Name: 2,4-Dibromo-3-chloropyridine
• CAS No.: 861024-77-3
• Molecular Formula: C₅H₂Br₂ClN
• Molecular Weight: 271.339
• Hs Code.: 2933399090
• European Community (EC) Number: 858-222-6
• DSSTox Substance ID: DTXSID10355735
• Wikidata: Q82134784
• Mol file: 861024-77-3.mol

Synonyms:2,4-dibromo-3-chloropyridine;861024-77-3;3-Chloro-2,4-dibromopyridine;SCHEMBL1337861;DTXSID10355735;MFCD00233992;AKOS024261395;BS-17668;CS-0106375;FT-0689491;D82856;EN300-120589;AC-907/25004318

Chemical Property of 2,4-Dibromo-3-chloropyridine

Chemical Property:

• Melting Point: 70-70.5 °C
• Boiling Point: 287.5±35.0 °C(Predicted)
• PKA: -1.06±0.10(Predicted)
• PSA: 12.89000
• Density: 2.136±0.06 g/cm3(Predicted)
• LogP: 3.26000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 270.82220
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99%, ^*data from raw suppliers

2,4-Dibromo-3-chloropyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=C1Br)Cl)Br

Technology Process of 2,4-Dibromo-3-chloropyridine

There total 2 articles about 2,4-Dibromo-3-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-pyridine-2,4-diol (103792-81-0) → 2,4-dibromo-3-chloro-pyridine (861024-77-3)

Guidance literature:

With phosphorus(V) oxybromide; at 180 ℃;

Reference yield:

5-bromo-4,6-dihydroxy-nicotinic acid → 2,4-dibromo-3-chloro-pyridine (861024-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; hydrochloric acid / 200 °C

2: phosphoryl bromide / 180 °C

With hydrogenchloride; water; phosphorus(V) oxybromide;

Reference yield:

2,4-dibromo-3-chloro-pyridine (861024-77-3) → 2-bromo-3-chloro-[4]pyridylamine + 4-bromo-3-chloropyridin-2-amine (861024-02-4)

Guidance literature:

With ammonium hydroxide; at 160 ℃;

upstream raw materials:

3-chloro-pyridine-2,4-diol

Downstream raw materials:

4-bromo-3-chloropyridin-2-amine