103792-81-0

Basic information

• Product Name: 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI)
• Synonyms: 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI);3-Chloro-2,4-dihydroxypyridine;2(1H)-Pyridinone, 3-chloro-4-hydroxy-;3-Chloro-4-hydroxy-2(1H)-pyridinone;3-chloro-4-hydroxy-1,2-dihydropyridin-2-one;3-Chloro-4-hydroxypyridin-2(1H)-one
• CAS NO: 103792-81-0
• Molecular Formula: C₅H₄ClNO₂
• Molecular Weight: 145.54
• EINECS: 258-441-1
• Product Categories: PYRIDINE
• Mol File: 103792-81-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 310 °C (decomp)
• Boiling Point: 283 ºC
• Flash Point: 125 ºC
• Appearance: /
• Density: 1.56
• Vapor Pressure: 0.00412mmHg at 25°C
• Refractive Index: 1.617
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI)(103792-81-0)
• EPA Substance Registry System: 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI)(103792-81-0)

Safety Data

• Hazardous Substances Data: 103792-81-0(Hazardous Substances Data)

Usage

General Description

2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI) is a chemical compound with the molecular formula C5H4ClNO2. It is a derivative of pyridinone, containing a chlorine atom and a hydroxy group. 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI) is used in the pharmaceutical industry as a precursor for the synthesis of various drugs and pharmaceuticals. It has also been studied for its potential biological and pharmacological activities, including its antibacterial and antiviral properties. Additionally, it has been used in the field of organic chemistry as a building block for the synthesis of more complex organic molecules. Overall, 2(1H)-Pyridinone,3-chloro-4-hydroxy-(9CI) is a versatile compound with various potential applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C5H4ClNO2/c6-4-3(8)1-2-7-5(4)9/h1-2H,(H2,7,8,9)

Upstream product

• 626-03-9 3-deazauracil 
• 96245-97-5 3-bromo-2,4-dihydroxypyridine 
• 626-03-9 4-hydroxy-2-pyridone 
• 7647-01-0 hydrogenchloride 
• 80791-79-3 5-bromo-pyridine-2,4-diol 

Downstream Products

• 55934-02-6 2,3,4-trichloropyridine 
• 861024-77-3 2,4-dibromo-3-chloro-pyridine 
• 873397-71-8 5-bromo-2,3,4-trichloro-pyridine 
• 861024-02-4 4-bromo-3-chloropyridin-2-amine 
• 188577-69-7 2-amino-3,4-dichloropyridine 
• 184416-83-9 4-amino-2,3-dichloropyridine 
• 128822-48-0 3-chloro-4-hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone 

Relevant articles and documents

Synthesis, Antitumor Activity, and Antiviral Activity of 3-Substituted 3-Deazacytidines and 3-Substituted 3-Deazauridines

Novel 3-substituted analogues of 4-amino-1-β-D-ribofuranosyl-2(1H)-pyridinone (3-deazacytidine, 3) and 4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone (3-deazauridine, 4) have been synthesized and tested for antitumor and antiviral activity.Thus the 3-chloro (9a), 3-bromo (9b), and 3-nitro (9c) analogues of 3 and the 3-chloro (9d), 3-bromo (9e), and 3-nitro (9f) analogues of 4 were prepared by standard glycosylating procedures.Novel requisite heterocycles 4-amino-3-chloro-2(1H)-pyridinone (7a) and 4-amino-3-bromo-2(1H)-pyridinone (7b) were prepared by halogenating4-amino-2(1H)-pyridinone (5).Requisite heterocycles 4-amino-3-nitro-2(1H)-pyridinone (7c), 3-chloro-4-hydroxy-2(1H)-pyridinone (7d), 3-bromo-4-hydroxy-2(1H)-pyridinone (7e), and 4-hydroxy-3-nitro-2(1H)-pyridinone (7f) were synthesized by known procedures from 4-hydroxy-2(1H)-pyridinone (6).Structure proof of target nucleosides was provided by independent synthesis, 1H NMR, and UV.Compounds 9a-f were devoid of activity against intraperitoneally implanted L1210 leukemia in mice.Compound 9f displayed significant activity against rhinovirus type 34 grown in WISH cells. 4-Amino-3-fluoro-1-β-D-ribofuranosyl-2(1H)-pyridinone (1) displayed good activity against intraperitoneally implanted P388 leukemia in mice, but it was devoid of activity against M5076 sarcoma, amelanotic (LOX) melanoma xenograft, and subrenal capsule human mammary carcinoma MX-1 xenograft in mice.Compound 1 also displayed significant activity against rhinovirus type 34.