(Trans-4-phenylpyrrolidin-3-yl)MethanaMine dihydrochloride

Base Information

• Chemical Name: (Trans-4-phenylpyrrolidin-3-yl)MethanaMine dihydrochloride
• CAS No.: 116169-49-4
• Molecular Formula: C11H18Cl2N2
• Molecular Weight: 176.261
• Mol file: 116169-49-4.mol

Synonyms:(Trans-4-phenylpyrrolidin-3-yl)MethanaMine dihydrochloride

Chemical Property of (Trans-4-phenylpyrrolidin-3-yl)MethanaMine dihydrochloride

Chemical Property:

• Boiling Point: 310.4±30.0 °C(Predicted)
• PKA: 10.12±0.29(Predicted)
• PSA: 38.05000
• Density: 1.014±0.06 g/cm3(Predicted)
• LogP: 3.58140

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

(TRANS-4-PHENYLPYRROLIDIN-3-YL)METHANAMINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Trans-4-phenylpyrrolidin-3-yl)MethanaMine dihydrochloride

There total 2 articles about (Trans-4-phenylpyrrolidin-3-yl)MethanaMine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-phenyl-1-(phenylmethyl)-3-pyrrolidinemethanamine (124563-10-6) → 4-phenyl-3-pyrrolidinemethanamine (116169-49-4)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; for 18h; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00164a060

Reference yield:

4-phenyl-1-(phenylmethyl)-3-pyrrolidinecarbonitrile (115687-28-0) → 4-phenyl-3-pyrrolidinemethanamine (116169-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / LiAlH₄ / tetrahydrofuran / 18 h / Ambient temperature

2: 84 percent / H₂, AcOH / 20percent Pd/C / methanol / 18 h / 2585.7 Torr / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00164a060

Reference yield: 64.0%

4-phenyl-3-pyrrolidinemethanamine (116169-49-4) + 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (94695-52-0) → 7-[[3-(aminomethyl)-4-phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid (124563-07-1,151821-18-0)

Guidance literature:

With triethylamine; In acetonitrile; 1.) reflux, 3 h, 2.) room temp., 18 h;

DOI:10.1021/jm00164a060

upstream raw materials:

4-phenyl-1-(phenylmethyl)-3-pyrrolidinemethanamine

4-phenyl-1-(phenylmethyl)-3-pyrrolidinecarbonitrile

Downstream raw materials:

7-[[3-(aminomethyl)-4-phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid

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