94695-52-0

Basic information

• Product Name: 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoq
• Synonyms: 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoq;1-Cyclopropyl-6,7,8-triflour-4-oxo-1,4-dihydro-quinolin-3-carbonsure;1-CYCLOPROPYL-6,7,8-TRIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDLEVOFLOXACIN;1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-;1-Cyclopropyl-1,4-dihydro-6,7,8-trifluoro-4-oxoquinoline-3-carboxylic Acid;Moxifloxacin Trifluoro IMpurity;1-cyclopropyl-6,7,8-trifluoro-4-oxoquinoline-3-carboxylic acid
• CAS NO: 94695-52-0
• Molecular Formula: C₁₃H₈F₃NO₃
• Molecular Weight: 283.204
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 94695-52-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 231-232℃
• Boiling Point: 431.252 °C at 760 mmHg
• Flash Point: 214.614 °C
• Appearance: /
• Density: 1.697
• Storage Temp.: 2-8°C
• PKA: 6.34±0.50(Predicted)
• CAS DataBase Reference: 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoq(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoq(94695-52-0)
• EPA Substance Registry System: 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoq(94695-52-0)

Safety Data

• Hazardous Substances Data: 94695-52-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Upstream product

• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 765-30-0 Cyclopropylamine 
• 7664-93-9 sulfuric acid 
• 94242-51-0 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 
• 94695-49-5 diethyl (2,3,4,5-tetrafluorobenzoyl)malonate 
• 94714-58-6 ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate 
• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 
• 94695-51-9 α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate 
• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 

Downstream Products

• 116169-42-7 7-[(3-amino-3-phenyl)-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 124563-02-6 7-[[3-(aminomethyl)-3-phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 128203-57-6 1-cyclopropyl-6,8-difluoro-7-(4-(R)-Cbz-amino-2-methylpyrazolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 124563-06-0 7-[(3-amino-4-phenyl)-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 124256-07-1 7-(2-Amino-phenylsulfanyl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 124256-14-0 7-(5-Amino-[1,3,4]thiadiazol-2-ylsulfanyl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 103460-90-8 AMQ4 
• 124256-08-2 7-(4-Amino-phenylsulfanyl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 99735-00-9 1-cyclopropyl-7-[3-[(methylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 99734-97-1 1-cyclopropyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 54012-73-6 (S)-piperidin-3-amine 
• 116169-46-1 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[(3-hydroxy-3-phenyl)-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid 
• 1130728-13-0 1-cyclopropyl-6,8-difluoro-4-oxo-7-phenoxy-1,4-dihydroquinoline-3-carboxylic acid 
• 1130728-02-7 1-cyclopropyl-6-fluoro-4-oxo-7,8-bis-phenylsulfanyl-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Carbostyril carboxylic compounds and intermediates, preparation method and application thereof

The invention discloses carbostyril carboxylic compounds and hydrochlorides thereof and also discloses a preparation method of the compounds and the hydrochlorides thereof as well as an application of the compounds and the hydrochlorides thereof in preparing gram-positive bacterium-preventing or gram-negative bacterium-preventing drugs. Moreover, the invention discloses intermediates for preparing the compounds and a preparation method of the intermediates.

Substituted naphthyridine-, quinoline- and benzoxazine- carboxylic acids as antibacterial agents and processes for their production

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1-Substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids. New Quantitative Structure-Activity Relationships at N1 for the Quinolone Antibacterials

A series of 18 1-substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (N1 analogues of CI-934) was synthesized and evaluated for antibacterial activity and DNA-gyrase inhibition.Correlations between the inhibition of DNA gyrase and antibacterial potency were established.A quantitative structure-activity relationship (QSAR) was derived by using the antibacterial potency of each of 11 strains of bacteria and the Gram-negative mean.The equations indicated that antibacterial potency was strongly dependent on STERIMOL length and width and the level of unsaturation of the N1 substituent.Some strains also showed a dependence on the presence of heteroatoms (O, N, S) in the N1 group.No significant correlations between gyrase inhibition and correlations of these parameters were found.These QSAR results are discussed in conjunction with the conformational analyses from molecular modeling studies.The substituent that most enhanced the activity of the quinolone in all regards was the cyclopropyl group.This analogue, 1-cyclopropyl-7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (PD 117558), demonstrated outstanding broad spectrum activity both in vitro and in vivo when compared to relevant standards.