(1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

Base Information

Chemical Name:(1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate
CAS No.:370880-79-8
Molecular Formula:C18H24N2O4
Molecular Weight:332.4
Hs Code.:
Mol file:370880-79-8.mol

Synonyms:(1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate;3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

Suppliers and Price of (1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
3-Benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate 97.0%
5 g
$ 2540.00

SynQuest Laboratories
3-Benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate 97.0%
1 g
$ 1540.00

SynQuest Laboratories
3-Benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate 97.0%
250 mg
$ 540.00

Crysdot
3-Benzyl6-tert-butyl3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate 95+%
1g
$ 565.00

Chemenu
3-Benzyl6-tert-butyl3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate 95%
1g
$ 528.00

American Custom Chemicals Corporation
3-BENZYL-6-TERT-BUTYL-3,6-DIAZABICYCLO[3.2.0]HEPTANE-3,6-DICARBOXYLATE 95.00%
5MG
$ 504.39

Alichem
3-Benzyl6-tert-butyl3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate
1g
$ 598.90

AK Scientific
3-Benzyl6-tert-butyl3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate
1g
$ 863.00

Total 6 raw suppliers

Chemical Property of (1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

Chemical Property:

Boiling Point:446.5±28.0 °C(Predicted)
PKA:-0.84±0.20(Predicted)
PSA：59.08000
Density:1.218±0.06 g/cm3(Predicted)
LogP:2.75010

Purity/Quality:

97% ^*data from raw suppliers

3-Benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate 97.0% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

There total 12 articles about (1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 122848-57-1
tert-butyl-3,6-diazabicyclo[3,2,0]heptane-6-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 370880-79-8
3-benzyl 6-(tert-butyl)-3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 370880-87-8
benzyl 3,6-diazabicyclo[3.2.0]heptane-3-carboxylate

: 370880-79-8
3-benzyl 6-(tert-butyl)-3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

Guidance literature:: In ethanol; water; at 20 ℃; for 0.666667h;

Reference yield:

: 114790-39-5
benzyl N-(2,2-dimethoxyethyl)carbamate

: 370880-79-8
3-benzyl 6-(tert-butyl)-3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / 50 °C / Inert atmosphere

2.1: formic acid / 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 20 °C / Inert atmosphere

4.1: pentan-1-ol / 20 h / 135 °C / Inert atmosphere

4.2: Raney Ni / 4 h / 3102.97 Torr

5.1: sodium hydrogencarbonate / ethanol; water; pentan-1-ol / 15 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 22.33 h / 0 - 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 20 h

7.2: pH ~ 12

8.1: sodium hydroxide / ethanol; water / 1.5 h / 60 °C

9.1: sodium hydroxide / ethanol; water / 0.67 h / 20 °C

With formic acid; hydroxylamine hydrochloride; sodium acetate; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; dichloromethane; pentan-1-ol; water; toluene; acetonitrile;