diethyl2-(cyclopropylMethyl)Malonate

Base Information

• Chemical Name: diethyl2-(cyclopropylMethyl)Malonate
• CAS No.: 37092-86-7
• Molecular Formula: C11H18O4
• Molecular Weight: 214.25822
• Mol file: 37092-86-7.mol

Synonyms:diethyl2-(cyclopropylMethyl)Malonate;Diethyl cyclopropylmethylmalonate

Chemical Property of diethyl2-(cyclopropylMethyl)Malonate

Chemical Property:

• PSA: 52.60000
• LogP: 1.52890

Purity/Quality:

98%Min ^*data from raw suppliers

diethyl2-(cyclopropylmethyl)malonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl2-(cyclopropylMethyl)Malonate

There total 3 articles about diethyl2-(cyclopropylMethyl)Malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diethyl 2-((3-oxocyclobutyl)methyl)malonate → 2-cyclopropylmethyl-malonic acid diethyl ester (37092-86-7)

Guidance literature:

[RhCl(cod)(1,3,4,5-tetramethylimidazol-2-ylidene)]; In m-xylene; for 6h; Heating;

DOI:10.1246/cl.2006.288

Reference yield: 85.0%

cyclopropylcarbinyl bromide (7051-34-5) + diethyl malonate (105-53-3) → 2-cyclopropylmethyl-malonic acid diethyl ester (37092-86-7)

Guidance literature:

diethyl malonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

cyclopropylcarbinyl bromide; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/acs.orglett.9b00142

Reference yield:

→ 2-cyclopropylmethyl-malonic acid diethyl ester (37092-86-7)

Guidance literature:

NaH, DMF, Bzl., 1. Diethylmalonat, 2. Cyclopropylmethylbromid, Δ;

DOI:10.1021/jm00276a004

upstream raw materials:

cyclopropylcarbinyl bromide

diethyl malonate