3,3-dimethyl-5-fluorooxindole

Base Information

• Chemical Name: 3,3-dimethyl-5-fluorooxindole
• CAS No.: 866209-99-6
• Molecular Formula: C₁₀H₁₀FNO
• Molecular Weight: 179.194
• Mol file: 866209-99-6.mol

Synonyms:3,3-dimethyl-5-fluorooxindole;5-fluoro-1,3-dihydro-3,3-diMethyl-2H-Indol-2-one;5-fluoro-3,3-dimethylindolin-2-one

Chemical Property of 3,3-dimethyl-5-fluorooxindole

Chemical Property:

• PSA: 32.59000
• LogP: 2.14050

Purity/Quality:

5-Fluoro-3,3-dimethylindolin-2-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-dimethyl-5-fluorooxindole

There total 4 articles about 3,3-dimethyl-5-fluorooxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-acetyl-5-fluoro-3,3-dimethylindolin-2-one (1158969-95-9) → 5-fluoro-3,3-dimethylindolin-2-one (866209-99-6)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; for 1.5h; Reflux;

Reference yield: 50.0%

5-fluoroindol-2(3H)-one (56341-41-4) + methyl iodide (74-88-4) → 5-fluoro-3,3-dimethylindolin-2-one (866209-99-6)

Guidance literature:

5-fluoroindol-2(3H)-one; With n-butyllithium; lithium chloride; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 18h;

DOI:10.1021/jm901559e

Reference yield:

C15H18FNO3 → 5-fluoro-3,3-dimethylindolin-2-one (866209-99-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201901619

upstream raw materials:

5-fluoroindol-2(3H)-one

methyl iodide

1-acetyl-5-fluoro-3,3-dimethylindolin-2-one

Refernces

• 1、 -. "FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS". Page/Page column 63. . Retrieved 2017/06/12.
• 2、 -. "CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS". Page/Page column 90. . Retrieved 2016/02/02.