3-Fur-2-ylaniline hydrochloride

Base Information

• Chemical Name: 3-Fur-2-ylaniline hydrochloride
• CAS No.: 1172481-22-9
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.648
• Hs Code.: 2921420090
• Mol file: 1172481-22-9.mol

Synonyms:3-Fur-2-ylaniline hydrochloride;2-(3-Aminophenyl)furan hydrochloride

Chemical Property of 3-Fur-2-ylaniline hydrochloride

Chemical Property:

• Melting Point: 145-147
• PSA: 39.16000
• LogP: 3.91200

Purity/Quality:

99% ^*data from raw suppliers

3-(Fur-2-yl)anilineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fur-2-ylaniline hydrochloride

There total 1 articles about 3-Fur-2-ylaniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

[3-(furan-2-yl)phenyl]carbamic acid tert-butyl ester (1190222-71-9) → 3-(furan-2-yl)aniline hydrochloride (1172481-22-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; Cooling with ice;

Reference yield: 77.0%

(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid (1103929-71-0) + 3-(furan-2-yl)aniline hydrochloride (1172481-22-9) → methyl 5-chloro-2-{[(2-{[3-(furan-2-yl)phenyl]amino}-2-oxoethoxy)acetyl]amino}benzoate (1190222-72-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl acetamide; at 20 ℃;

DOI:10.1016/j.bmcl.2017.11.016

Reference yield:

(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid (1103929-71-0) + 3-(furan-2-yl)aniline hydrochloride (1172481-22-9) → 5-chloro-2-([(2-([3-(furan-2-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid (1190221-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl acetamide / 20 °C

2: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1016/j.bmcl.2017.11.016

upstream raw materials:

[3-(furan-2-yl)phenyl]carbamic acid tert-butyl ester

Downstream raw materials:

methyl 5-chloro-2-{[(2-{[3-(furan-2-yl)phenyl]amino}-2-oxoethoxy)acetyl]amino}benzoate

5-chloro-2-([(2-([3-(furan-2-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid

Refernces