ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate

Base Information

• Chemical Name: ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate
• CAS No.: 243984-26-1
• Molecular Formula: C9H13ClO4S
• Molecular Weight: 252.719
• Mol file: 243984-26-1.mol

Synonyms:ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate

Chemical Property of ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate

Chemical Property:

• Melting Point: 32-33 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 347.6±42.0 °C(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate

There total 6 articles about ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

ethyl 2-mercaptocyclohex-1-ene-1-carboxylate (54928-91-5) → ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate (243984-26-1)

Guidance literature:

With water; chlorine; In acetic acid; at 15 ℃; for 0.833333h;

Reference yield:

2-(ethoxycarbonyl)cyclohex-1-ene-1-sulfonic acid (243984-25-0) → ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate (243984-26-1)

Guidance literature:

With thionyl chloride; for 14h; Heating;

DOI:10.1021/jm050623t

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate (243984-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂S(gas) / ethanol / 2 h / -50 °C

1.2: HCl(gas) / ethanol / 2 h / -20 °C

1.3: 73 percent / H₂S(gas) / ethanol / 16 h / -20 °C

2.1: 74 percent / Cl₂(gas); aq. AcOH / 0.83 h / 15 °C

With hydrogen sulfide; chlorine; acetic acid; In ethanol;

DOI:10.1021/jm050623t

upstream raw materials:

2-(ethoxycarbonyl)cyclohex-1-ene-1-sulfonic acid

ethyl 2-mercaptocyclohex-1-ene-1-carboxylate

ethyl 2-oxocyclohexane carboxylate

ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate

Downstream raw materials:

ethyl 6-[N-(4-chloro-2-fluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate

d-ethyl 6-[N-(2,4-difluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate

ethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate