2-Methoxy-3-pivalamidoisonicotinic acid

Base Information

• Chemical Name: 2-Methoxy-3-pivalamidoisonicotinic acid
• CAS No.: 705291-48-1
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.27
• Hs Code.: 2933399090
• Mol file: 705291-48-1.mol

Synonyms:2-Methoxy-3-pivalamidoisonicotinic acid

Chemical Property of 2-Methoxy-3-pivalamidoisonicotinic acid

Chemical Property:

• PSA: 88.52000
• LogP: 1.84600

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxy-3-pivalamidoisonicotinicacid ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-Methoxy-3-pivalamidoisonicotinic acid

There total 1 articles about 2-Methoxy-3-pivalamidoisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

carbon dioxide (124-38-9,18923-20-1) + N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide (125867-19-8) → 3-(tert-butylcarbonylamino)-2-methoxyisonicotinic acid (705291-48-1)

Guidance literature:

N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -10 ℃; for 3h;

carbon dioxide; In diethyl ether; for 1h; Further stages.; cooling;

DOI:10.1016/j.tet.2004.02.040

Reference yield:

3-(tert-butylcarbonylamino)-2-methoxyisonicotinic acid (705291-48-1) → 2-tert-butyl-8-methoxy-5-phenylthiopyrido[3,4-d]pyrimidin-4(3H)-one

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic anhydride / 2 h / Heating

2.1: NH₃ / 24 h / 20 °C

2.2: 5.93 g / NaOH / H₂O / 0.25 h / Heating

3.1: 2,2,6,6-tetramethylpiperidine; n-BuLi / tetrahydrofuran; hexane / 1 h / -20 °C

3.2: 89 percent / tetrahydrofuran; hexane / 1 h / -78 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ammonia; acetic anhydride; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2004.02.040

Reference yield:

3-(tert-butylcarbonylamino)-2-methoxyisonicotinic acid (705291-48-1) → 2-tert-butyl-5-(hydroxy(phenyl)methyl)-8-methoxypyrido[3,4-d]pyrimidin-4(3H)-one

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic anhydride / 2 h / Heating

2.1: NH₃ / 24 h / 20 °C

2.2: 5.93 g / NaOH / H₂O / 0.25 h / Heating

3.1: 2,2,6,6-tetramethylpiperidine; n-BuLi / tetrahydrofuran; hexane / 1 h / -20 °C

3.2: 85 percent / tetrahydrofuran; hexane / 1 h / -78 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ammonia; acetic anhydride; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2004.02.040

upstream raw materials:

carbon dioxide

N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide

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