Boc-HPh-Leu-Phe-OMe

Base Information

• Chemical Name: Boc-HPh-Leu-Phe-OMe
• CAS No.: 868539-96-2
• Molecular Formula: C31H43N3O6
• Molecular Weight: 553.699
• Mol file: 868539-96-2.mol

Synonyms:Boc-HPh-Leu-Phe-OMe;L-Phenylalanine, (αS)-α-[[(1,1-dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-, methyl ester;N-[(S)-2-(tert-Butoxycarbonylamino)-4-phenylbutanoyl]-L-leucyl-L-phenylalanine methyl ester

Chemical Property of Boc-HPh-Leu-Phe-OMe

Chemical Property:

• Boiling Point: 753.4±60.0 °C(Predicted)
• PKA: 11.22±0.46(Predicted)
• PSA: 122.83000
• Density: 1.123±0.06 g/cm3(Predicted)
• LogP: 5.11660
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(6S,9S,12S)-Methyl12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-HPh-Leu-Phe-OMe

There total 11 articles about Boc-HPh-Leu-Phe-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-L-homophenylalanine (82732-07-8,108524-68-1,142926-43-0,100564-78-1) + Leu-Phe-OMe trifluoroacetate → (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate (868539-96-2)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

Reference yield:

(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester (15136-32-0,87976-66-7,120342-25-8,5874-73-7) + Boc-L-homophenylalanine (82732-07-8,108524-68-1,142926-43-0,100564-78-1) → (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate (868539-96-2)

Guidance literature:

(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Boc-L-homophenylalanine; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + L-leucyl-L-phenylalanine methyl ester (38155-18-9) → (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate (868539-96-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

Boc-L-homophenylalanine

N-tert-butoxycarbonyl-L-phenylalanine

L-leucyl-L-phenylalanine methyl ester

N-tert-butoxycarbonyl-L-leucine

Downstream raw materials:

C₂HF₃O₂*C₂₆H₃₅N₃O₄

C₂₈H₃₆ClN₃O₅

C₃₂H₄₄N₄O₆

(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Refernces

• 1、 Xie, Stanley C.,Gillett, David L.,Spillman, Natalie J.,Tsu, Christopher,Luth, Madeline R.,Ottilie, Sabine,Duffy, Sandra,Gould, Alexandra E.,Hales, Paul,Seager, Benjamin A.,Charron, Carlie L.,Bruzzese, Frank,Yang, Xiaofeng,Zhao, Xiansi,Huang, Shih-Chung,Hutton, Craig A.,Burrows, Jeremy N.,Winzeler, Elizabeth A.,Avery, Vicky M.,Dick, Lawrence R.,Tilley, Leann. "Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome". . p. 10053 - 10066. Retrieved 2018/11/23.
• 2、 -. "CRYSTALLINE PEPTIDE EPOXY KETONE PROTEASE INHIBITORS AND THE SYNTHESIS OF AMINO ACID KETO-EPOXIDES". . . Retrieved 2016/10/27.