(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL

Base Information

Chemical Name:(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL
CAS No.:1212932-15-4
Molecular Formula:C8H9F2NO
Molecular Weight:173.16
Hs Code.:
Mol file:1212932-15-4.mol

Synonyms:(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL;(S)-2-Amino-2-(3,5-difluorophenyl)ethanol;(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL HCl

Suppliers and Price of (2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-2-Amino-2-(3,5-difluorophenyl)ethanol 95+%
1g
$ 650.00

Crysdot
(S)-2-Amino-2-(3,5-difluorophenyl)ethanol 95+%
250mg
$ 260.00

American Custom Chemicals Corporation
(2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL 95.00%
5MG
$ 504.38

Alichem
(S)-2-Amino-2-(3,5-difluorophenyl)ethanol
1g
$ 643.50

Total 8 raw suppliers

Chemical Property of (2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL

Chemical Property:

Boiling Point:275.8±35.0 °C(Predicted)
PKA:12.26±0.10(Predicted)
PSA：46.25000
Density:1.305±0.06 g/cm3(Predicted)
LogP:1.65720
Storage Temp.:2-8°C

Purity/Quality:

95% ^*data from raw suppliers

(S)-2-Amino-2-(3,5-difluorophenyl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL

There total 8 articles about (2S)-2-AMINO-2-(3,5-DIFLUOROPHENYL)ETHAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (S)-4-(3,5-difluorophenyl)-[1,2,3]-oxathiazolidine 2,2-dioxide

: 1212932-15-4
(S)-2-amino-2-(3,5-difluorophenyl)ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; enantioselective reaction; Inert atmosphere; Reflux;
DOI:10.1002/adsc.201801566

Reference yield: 75.0%

: 1589473-81-3
(S)-2-azido-2-(3,5-difluorophenyl)ethanol

: 1212932-15-4
(S)-2-amino-2-(3,5-difluorophenyl)ethanol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 4h; Inert atmosphere;
DOI:10.1002/ardp.201300283

Reference yield:

: 1589473-76-6
(R)-4-benzyl-3-(2-(3,5-difluorophenyl)acetyl)oxazolidin-2-one

: 1212932-15-4
(S)-2-amino-2-(3,5-difluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 1.25 h / -78 - 0 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: sodium azide / acetonitrile / 7 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran; water / 24.5 h / 0 - 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

With lithium borohydride; sodium azide; di-n-butylboryl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ardp.201300283