(S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

Base Information

Chemical Name:(S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide
CAS No.:1589473-85-7
Molecular Formula:C₁₄H₁₂ClF₂NO₃S
Molecular Weight:347.77
Hs Code.:

Synonyms:(S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

Suppliers and Price of (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

Chemical Property:

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Technology Process of (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

There total 6 articles about (S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1212932-15-4
(S)-2-amino-2-(3,5-difluorophenyl)ethanol

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1589473-85-7
(S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

Guidance literature:: (S)-2-amino-2-(3,5-difluorophenyl)ethanol; With pyridine; In dichloromethane; at 20 ℃; for 0.25h;

4-chlorobenzenesulfonyl chloride; In dichloromethane; for 24h;
DOI:10.1002/ardp.201300283

Reference yield:

: 1589473-76-6
(R)-4-benzyl-3-(2-(3,5-difluorophenyl)acetyl)oxazolidin-2-one

: 1589473-85-7
(S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 1.25 h / -78 - 0 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: sodium azide / acetonitrile / 7 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran; water / 24.5 h / 0 - 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

5.1: pyridine / dichloromethane / 0.25 h / 20 °C

5.2: 24 h

With pyridine; lithium borohydride; sodium azide; di-n-butylboryl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ardp.201300283

Reference yield:

: 1589473-77-7
(R)-4-benzyl-3-((R)-2-bromo-2-(3,5-difluorophenyl)acetyl)oxazolidin-2-one

: 1589473-85-7
(S)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / acetonitrile / 7 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran; water / 24.5 h / 0 - 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

4.1: pyridine / dichloromethane / 0.25 h / 20 °C

4.2: 24 h

With pyridine; lithium borohydride; sodium azide; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ardp.201300283