Ethanone, 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-

Base Information

• Chemical Name: Ethanone, 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-
• CAS No.: 1011711-52-6
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.62
• Hs Code.: 2933998090
• Mol file: 1011711-52-6.mol

Synonyms:Ethanone, 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-;3-Acetyl-4-chloro-7-azaindole;1-(4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANONE;1-{4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-one

Chemical Property of Ethanone, 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-

Chemical Property:

• PSA: 45.75000
• LogP: 2.41890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Acetyl-4-chloro-7-azaindole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-

There total 2 articles about Ethanone, 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetic anhydride (108-24-7) + 4-chloro-7-azaindole (55052-28-3) → 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethenone (1011711-52-6)

Guidance literature:

With trifluoroacetic acid; for 8h; Heating;

DOI:10.1021/jm700940h

Reference yield: 77.0%

acetyl chloride (75-36-5) + 4-chloro-7-azaindole (55052-28-3) → 1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethenone (1011711-52-6)

Guidance literature:

4-chloro-7-azaindole; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 1.5h;

acetyl chloride; In dichloromethane; at 20 ℃; Inert atmosphere;

With water; sodium hydroxide; In ethyl acetate;

Reference yield: 98.1%

1-(4-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethenone (1011711-52-6) + p-toluenesulfonyl chloride (98-59-9) → C16H13ClN2O3S

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 2h; Time; Cooling with ice; Reflux;

upstream raw materials:

acetic anhydride

4-chloro-7-azaindole

acetyl chloride

Downstream raw materials:

3-acetyl-1-benzenesulfonyl-4-chloro-1H-pyrrolo[2,3-b]pyridine

Refernces

• 1、 -. "Method for synthesizing Meriolin". Paragraph 0009; 0041; 0046-0047; 0054; 0059-0060; 0067; 0073. . Retrieved 2019/07/01.
• 2、 Liu, Bin,Yuan, Xia,Xu, Bo,Zhang, Han,Li, Ridong,Wang, Xin,Ge, Zemei,Li, Runtao. "Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors". . p. 1 - 15. Retrieved 2019/03/17.