1H-Indene, 2-ethynyl- (9CI)

Base Information

• Chemical Name: 1H-Indene, 2-ethynyl- (9CI)
• CAS No.: 74010-34-7
• Molecular Formula: C11H8
• Molecular Weight: 140.18122
• Hs Code.: 2902909090
• Mol file: 74010-34-7.mol

Synonyms:1H-Indene, 2-ethynyl- (9CI)

Chemical Property of 1H-Indene, 2-ethynyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.151mmHg at 25°C
• Boiling Point: 222.5°C at 760 mmHg
• Flash Point: 76.5°C
• PSA: 0.00000
• Density: 1.06g/cm³
• LogP: 2.25930

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indene, 2-ethynyl- (9CI)

There total 3 articles about 1H-Indene, 2-ethynyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C14H16Si → 2-Ethinyl-1H-inden (74010-34-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1039/c4dt01583e

Reference yield:

2-bromoindene (10485-09-3) → 2-Ethinyl-1H-inden (74010-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tri-tert-butyl phosphine; diisopropylamine; bis(benzonitrile)palladium(II) dichloride / toluene / 6 h / 20 °C / Inert atmosphere

2: potassium carbonate / dichloromethane; methanol / 1 h / 0 - 28 °C / Inert atmosphere

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; potassium carbonate; diisopropylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/ja412634w

Reference yield:

→ 2-Ethinyl-1H-inden (74010-34-7)

Guidance literature:

Naphthocyclopropen, Δ;

DOI:10.1016/S0040-4039(01)86558-8

upstream raw materials:

2-bromoindene

Downstream raw materials:

4-(2-formylphenyl)-N-methyl-N-(methylsulfonyl)-N'-phenylbut-2-ynimidamide

Refernces

• 1、 Gawade, Sagar Ashok,Huple, Deepak B.,Liu, Rai-Shung. "Zn(II)- or Ag(I)-catalyzed 1,4-metathesis reactions between 3-en-1-ynamides and nitrosoarenes". . p. 2978 - 2981. Retrieved 2014/03/21.