Ethyl 4-(4-(4-chlorophenoxy)phenyl)-2,4-dioxobutanoate

Base Information

• Chemical Name: Ethyl 4-(4-(4-chlorophenoxy)phenyl)-2,4-dioxobutanoate
• CAS No.: 74649-80-2
• Molecular Formula: C18H15ClO5
• Molecular Weight: 346.767
• Mol file: 74649-80-2.mol

Synonyms:Ethyl 4-(4-(4-chlorophenoxy)phenyl)-2,4-dioxobutanoate;4-[4-(4-Chloro-phenoxy)-phenyl]-2,4-dioxo-butyric acid ethyl ester

Chemical Property of Ethyl 4-(4-(4-chlorophenoxy)phenyl)-2,4-dioxobutanoate

Chemical Property:

• PSA: 69.67000
• LogP: 3.83730

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 4-(4-(4-CHLOROPHENOXY)PHENYL)-2,4-DIOXOBUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-(4-(4-chlorophenoxy)phenyl)-2,4-dioxobutanoate

There total 3 articles about Ethyl 4-(4-(4-chlorophenoxy)phenyl)-2,4-dioxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-[4-(4-chlorophenoxy)phenyl]ethanone (41150-48-5) + oxalic acid diethyl ester (95-92-1) → ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-oxopropionate (74649-80-2)

Guidance literature:

1-[4-(4-chlorophenoxy)phenyl]ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h;

oxalic acid diethyl ester; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-oxopropionate (74649-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 120 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C

2.2: 1 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-oxopropionate (74649-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 120 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C

2.2: 1 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

1-[4-(4-chlorophenoxy)phenyl]ethanone

oxalic acid diethyl ester

1-(4-fluorophenyl)ethanone

4-chloro-phenol

Downstream raw materials:

ethyl 3-(4-(4-chlorophenoxy)phenyl)-1H-pyrazole-5-carboxylate

ethyl 3-(4-(4-chlorophenoxy)phenyl)isoxazole-5-carboxylate

N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-chlorophenoxy)phenyl)-1H-pyrazole-5-carboxamide

N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-chlorophenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Refernces

• 1、 Tomisawa,Kameo,Matsunaga,Saito,Hosoda,Asami,Sota. "Studies on hypolipidemic agents. II. 3-(4-phenoxybenzoyl)propionic acid derivatives". . p. 2386 - 2394. Retrieved 2007/10/02.