41150-48-5

Usage

Uses

Used in Pharmaceutical Industry:
4'-(4-Chlorophenoxy)acetophenone is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones.
Used in Organic Synthesis:
4'-(4-Chlorophenoxy)acetophenone is used as a reagent in organic synthesis, facilitating the creation of a range of organic compounds for various applications, including the production of dyes, fragrances, and agrochemicals.
Used in Aromatic Chemicals Production:
4'-(4-Chlorophenoxy)acetophenone is used as a building block in the production of various aromatic chemicals, which are essential components in the formulation of a wide array of consumer products, such as perfumes, plastics, and coatings.

Upstream product

• 7005-72-3 4-chlorodiphenyl ether 
• 75-36-5 acetyl chloride 
• 99-90-1 para-bromoacetophenone 
• 106-48-9 4-chloro-phenol 
• 86-55-5 1-naphthalenecarboxylic acid 
• 85014-03-5 (4-chlorophenoxymethyl)-(4-fluorophenyl)-ketone 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 30427-95-3 1-bromo-4-(4-chlorophenoxy)benzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 13329-40-3 4-Iodoacetophenone 
• 1193-00-6 sodium 4-chlorophenolate 

Downstream Products

• 38110-15-5 (E)-3-[4-(4-Chloro-phenoxy)-phenyl]-but-2-enoic acid methyl ester 
• 74649-80-2 ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-oxopropionate 
• 100281-34-3 3-<4-(4-chlorophenoxy)benzoyl>-2-hydroxypropionic acid 
• 105769-20-8 4-(4-chlorophenoxy)phenyl 2,2-bis(methylthio)vinyl ketone 
• 86896-97-1 4-chlorophenyl 4-(hydroxyisopropyl)phenyl ether 
• 21120-67-2 4-(4'-chlorophenoxy)-benzoic acid 
• 58727-42-7 3-p-(p-chlorophenoxy)-phenyl-3-hydroxybutyric acid ethyl ester 
• 13221-80-2 2-chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone 
• 1612765-04-4 1-chloro-2-[4-(4-chlorophenoxy)phenyl]pent-3-yn-2-ol 
• 1612764-98-3 1-(1,2,4-triazole)-2-[4-(4-chlorophenoxy)phenyl]pent-3-yn-2-ol 
• 84447-83-6 α-bromo-4-(4-chlorophenoxy)acetophenone 
• 1609174-07-3 N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-chlorophenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1609174-08-4 N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(4-chlorophenoxy)phenyl)-1H-pyrazole-5-carboxamide 
• 1609174-28-8 ethyl 3-(4-(4-chlorophenoxy)phenyl)isoxazole-5-carboxylate 

Relevant academic research and scientific papers

Preparation method of diaryl ether compound

The invention relates to a preparation method of a diaryl ether compound. Particularly, under catalysis of chitosan supported cuprous oxide, an arylation reaction used for phenols is achieved, the corresponding diaryl ether compound is obtained, the technological condition is simple, the yield is good, operability is high, and wide functional group durability is achieved.

Antibacterial synergist, preparation method and uses thereof

The present invention relates to an antibacterial synergist, a preparation method and uses thereof, and specifically discloses a compound represented by a formula (I) and having antibacterial synergyactivity, or an optical isomer, a cis-trans isomer or a pharmaceutically acceptable salt thereof, and a preparation method thereof. The present invention further discloses a medical composition containing the compound, and uses thereof. According to the present invention, the compound can effectively enhance the antibacterial activity of polymyxin B against Acinetobacter baumannii and Klebsiella pneumoniae, and can be used for the antibacterial treatment of pathogenic bacteria insensitive to polymyxin or having low bacterial inhibition activity. The formula (I) is defined in the specification.

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

A hydrogen-transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield), is reported. Taking advantage of the hydrogen-transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

With substituted pyrazine and imidazole derivatives, their preparation and their use in medicine (by machine translation)

The invention discloses a substituted pyrazine and imidazole derivatives, their preparation and their use in medicine. Specifically, the invention relates to a compound of general formula (I) indicated by the new derivative and its pharmaceutically acceptable salt or pharmaceutical composition containing the same, and its preparation method. The invention also discloses the derivative and its pharmaceutically acceptable salt or pharmaceutical composition containing the same in the Bruton tyrosine kinase inhibitors, and in preparing and treating and/or preventing tumor diseases such as inflammation of the application of the medicament. Wherein the general formula (I) of each substituent as defined in the specification. (by machine translation)

Novel heteroarylcarboxamide derivative or pharmacutically acceptable salt thereof, process for the preparation thereof and pharmaceutical composition for prevention or treatment of RAGE receptor related diseases containing the same as an active ingredient

The present invention refers to novel heterocyclic biting Carbox probably the id derivative acceptable salt, and manufacturing method thereof including RAGE associated active acetylcholinesterase receptor or pharmaceutical composition for preventing or treating disease is directed to. Heterocycle by the present invention a derivative biting Carbox probably the id RAGE receptor antagonism in by, nerve cells with the beta loss oh with wheat id RAGE conjunction with receptor, inhibiting moving into brain, the resulting beta Amyloid plaque formed 21 is known to effectively inhibit generation.. Furthermore, memory a chemicals that are important in the acetylcholine for decomposing an aromatic thus inhibiting acetylcholine s reel sacrifice , RAGE disease associated active acetylcholinesterase receptor or Alzheimer's disease, cerebrovascular dementia, dementia due to damage bean curd, multi blockade dementia, Alzheimer's disease or the like dementia alcoholic or mixed dementia multi blockade and including dementia, pick (pick) bottle, a smartcrew [...] -Jakob (Creutzfeldt-jakob) bottle, that thyroid gland symptoms , bean curd a blade Parkinson (Parkinson) bottle, Huntington's disease (Huntington) which is useful in preventing or treating, can be used.

Copper-catalyzed Ullmann-type synthesis of diaryl ethers assisted by salicylaldimine ligands

A series of salicylaldimine ligands were designed to promote the copper-catalyzed Ullmann cross-coupling reaction. After a screening process, 2-((2-isopropylphenylimino)methyl)phenol was found to serve as a good supporting ligand for this reaction. Employing this Schiff-base ligand as a new supporting ligand, the copper-catalyzed coupling reactions of aryl bromides and aryl iodides with various phenols successfully proceeded in good yields under mild conditions. Various diaryl ethers were obtained with excellent yields in dioxane in the presence of K3PO4 and a catalytic amount of copper(I) salt.

Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE)

In an effort to develop novel inhibitors of receptor for advanced glycation end products (RAGE) for the treatment of Alzheimer's disease, a series of pyrazole-5-carboxamides were designed, synthesized and biologically evaluated. Analyses of the extensive

SUBSTITUTED 2-[PHENOXY-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS AND THEIR USE AS FUNGICIDES

The present invention relates to substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula (I) as defined in the description, and the N-oxides, and salts thereof, their preparation and intermediates for preparing them. The invention also relates to the use of these compounds for combating harmful fungi and seed coated with at least one such compound and also to compositions comprising at least one such compound.

Ullmann-type coupling reaction using metal-organic framework MOF-199 as an efficient recyclable solid catalyst

A highly porous metal-organic framework (MOF-199) was synthesized, and characterized by several methods including XRD, SEM, TEM, TGA, FT-IR, AAS, and nitrogen physisorption measurements. The MOF-199 was used as an efficient recyclable solid catalyst for the Ullmann-type reaction between aryl iodides and phenols to form diaryl ethers. High conversions were achieved for the transformation at the catalyst concentration of 5 mol%, in the presence of MeONa as a base. Due to the rare availability and the high cost, Cs 2CO3 should only be used for the case of deactivated aryl iodides or deactivated phenols. The MOF-199 catalyst could be facilely separated from the reaction mixture by simple filtration, and could be reused several times without a significant degradation in catalytic activity. The Ullmann-type reaction could only proceed in the presence of the solid MOF-199 catalyst, and the contribution from leached active species in the liquid phase, if any, was negligible.

Methenamine as an efficient ligand for copper-catalyzed coupling of phenols with aryl halides

Employing methenamine as a new supporting ligand, the copper-catalyzed coupling reactions of aryl bromides or aryl iodides with various phenols successfully proceeded in good yields under mild conditions. A series of diaryl ethers were obtained with excellent yields in the presence of K 3PO4 and copper(I) salt. Copyright