(2-Bromo-3-fluoro-phenyl)-acetic acid

Base Information

• Chemical Name: (2-Bromo-3-fluoro-phenyl)-acetic acid
• CAS No.: 958454-33-6
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.037
• Hs Code.: 2916399090
• Mol file: 958454-33-6.mol

Synonyms:(2-Bromo-3-fluoro-phenyl)-acetic acid;2-Bromo-3-fluorobenzeneacetic acid

Chemical Property of (2-Bromo-3-fluoro-phenyl)-acetic acid

Chemical Property:

• Vapor Pressure: 0.000229mmHg at 25°C
• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• PSA: 37.30000
• Density: 1.697g/cm³
• LogP: 2.21530
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-fluorophenylacetic acid 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Bromo-3-fluoro-phenyl)-acetic acid

There total 3 articles about (2-Bromo-3-fluoro-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H4BrFN2O → 2-(2-bromo-3-fluorophenyl)acetic acid (958454-33-6)

Guidance literature:

With water monomer; silver(I) acetate; In 1,4-dioxane; at 0 - 70 ℃; for 2h;

DOI:10.1021/acs.jmedchem.1c01813

Reference yield:

2-bromo-3-fluoro-benzoic acid (132715-69-6) → 2-(2-bromo-3-fluorophenyl)acetic acid (958454-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: acetonitrile; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

3: water monomer; silver(I) acetate / 1,4-dioxane / 2 h / 0 - 70 °C

With oxalyl dichloride; water monomer; silver(I) acetate; N,N-dimethyl-formamide; In 1,4-dioxane; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1021/acs.jmedchem.1c01813

Reference yield:

2-bromo-3-fluorobenzoyl chloride (1000339-91-2) → 2-(2-bromo-3-fluorophenyl)acetic acid (958454-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2: water monomer; silver(I) acetate / 1,4-dioxane / 2 h / 0 - 70 °C

With water monomer; silver(I) acetate; In 1,4-dioxane; diethyl ether; acetonitrile;

DOI:10.1021/acs.jmedchem.1c01813

upstream raw materials:

2-bromo-3-fluoro-benzoic acid

2-bromo-3-fluorobenzoyl chloride

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