[3aS-(3a,4,5,6a)]-(9CI)-4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]hexahydro-5-hydroxy-2(1H)-pentalenone

Base Information

Chemical Name:[3aS-(3a,4,5,6a)]-(9CI)-4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]hexahydro-5-hydroxy-2(1H)-pentalenone
CAS No.:81266-61-7
Molecular Formula:C₁₅H₂₈O₃Si
Molecular Weight:284.471
Hs Code.:
Mol file:81266-61-7.mol

Synonyms:[3aS-(3a,4,5,6a)]-(9CI)-4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]hexahydro-5-hydroxy-2(1H)-pentalenone;[3aS-(3aalpha,4alpha,5beta,6aalpha)]-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]hexahydro-5-hydroxy-2(1H)-Pentalenone

Suppliers and Price of [3aS-(3a,4,5,6a)]-(9CI)-4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]hexahydro-5-hydroxy-2(1H)-pentalenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of [3aS-(3a,4,5,6a)]-(9CI)-4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]hexahydro-5-hydroxy-2(1H)-pentalenone

Chemical Property:

PSA：46.53000
LogP:2.98430

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [3aS-(3a,4,5,6a)]-(9CI)-4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]hexahydro-5-hydroxy-2(1H)-pentalenone

There total 8 articles about [3aS-(3a,4,5,6a)]-(9CI)-4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]hexahydro-5-hydroxy-2(1H)-pentalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79745-56-5,81205-35-8,81205-36-9
(3aS,5R,6aS)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-hydroxy-2-oxo-octahydro-pentalene-1-carboxylic acid ethyl ester

: 81266-61-7
(3aS,5R,6aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-hydroxy-hexahydro-pentalen-2-one

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In water; toluene; at 110 ℃;

Reference yield:

: 39746-00-4,53275-42-6,53275-53-9,81244-64-6,93133-00-7,172821-93-1
Benzoic acid (3aR,5R,6aS)-4-hydroxymethyl-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

: 81266-61-7
(3aS,5R,6aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-hydroxy-hexahydro-pentalen-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide

2: tetrahydrofuran / -70 °C

3: TsOH / toluene / 25 °C

4: K₂CO₃ / methanol / 25 °C

5: Collins-reagent / or Jones-reagent

6: 1.) 1,5-diazabicyclo<4.3.0>non-5-ene, 2.) NaBH₄ / 1.) 0 deg C, THF, 2.) CH₃OH

7: 1,4-diazabicyclo<2.2.2>octane / toluene; H₂O / 110 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; sodium tetrahydroborate; Collins oxidation agent; DBN; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 81266-61-7
(3aS,5R,6aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-hydroxy-hexahydro-pentalen-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide

2: tetrahydrofuran / -70 °C

3: TsOH / toluene / 25 °C

4: K₂CO₃ / methanol / 25 °C

5: Collins-reagent / or Jones-reagent

6: 1.) 1,5-diazabicyclo<4.3.0>non-5-ene, 2.) NaBH₄ / 1.) 0 deg C, THF, 2.) CH₃OH

7: 1,4-diazabicyclo<2.2.2>octane / toluene; H₂O / 110 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; sodium tetrahydroborate; Collins oxidation agent; DBN; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;