1H-Indene,5-fluoro-1-methyl-,(R)-(9CI)

Base Information

• Chemical Name: 1H-Indene,5-fluoro-1-methyl-,(R)-(9CI)
• CAS No.: 170941-17-0
• Molecular Formula: C₁₀H₉F
• Molecular Weight: 148.18
• Mol file: 170941-17-0.mol

Synonyms:1H-Indene,5-fluoro-1-methyl-,(R)-(9CI)

Chemical Property of 1H-Indene,5-fluoro-1-methyl-,(R)-(9CI)

Chemical Property:

• Boiling Point: 212.6±29.0 °C(Predicted)
• Density: 1.089±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indene,5-fluoro-1-methyl-,(R)-(9CI)

There total 8 articles about 1H-Indene,5-fluoro-1-methyl-,(R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)-6-Fluoro-3-methyl-indan-1-ol → (+)-(S)-5-fluoro-1-methylindene (170941-14-7,170941-17-0,170941-20-5)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 0.5h; Heating;

DOI:10.3891/acta.chem.scand.52-0911

Reference yield:

(S)-3-methyl-1-indanone (935-77-3,22573-38-2) → (+)-(S)-5-fluoro-1-methylindene (170941-14-7,170941-17-0,170941-20-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 66 percent / KNO₃, conc. H₂SO₄ / 2.5 h / 3 - 8 °C

2: 91 percent / CaCl₂, activated Zn dust / ethanol; H₂O / 5 h / Heating

3: 70 percent / conc. HCl, NaNO₂, 48percent HBF₄ / H₂O / 45 h / 0 °C

4: 38 percent / toluene / 1.5 h / Heating

5: 91 percent / NaBH₄ / methanol / 3 h / Ambient temperature

6: 76 percent / p-TsOH*H₂O / benzene / 0.5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; tetrafluoroboric acid; sulfuric acid; toluene-4-sulfonic acid; potassium nitrate; calcium chloride; zinc; sodium nitrite; In methanol; ethanol; water; toluene; benzene;

DOI:10.3891/acta.chem.scand.52-0911

Reference yield:

(S)-6-amino-3-methylindan-1-one (210759-96-9) → (+)-(S)-5-fluoro-1-methylindene (170941-14-7,170941-17-0,170941-20-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / conc. HCl, NaNO₂, 48percent HBF₄ / H₂O / 45 h / 0 °C

2: 38 percent / toluene / 1.5 h / Heating

3: 91 percent / NaBH₄ / methanol / 3 h / Ambient temperature

4: 76 percent / p-TsOH*H₂O / benzene / 0.5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; tetrafluoroboric acid; toluene-4-sulfonic acid; sodium nitrite; In methanol; water; toluene; benzene;

DOI:10.3891/acta.chem.scand.52-0911

upstream raw materials:

5-fluoro-1-methylindene

(S)-3-methyl-1-indanone

(S)-6-amino-3-methylindan-1-one

(S)-6-fluoro-3-methylindan-1-one

Downstream raw materials:

(-)-(R)-5-fluoro-1-methylindene

(+)-(S)-5-fluoro-1-methylindene