7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-6-(4-Methoxyphenyl)-

Base Information

• Chemical Name: 7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-6-(4-Methoxyphenyl)-
• CAS No.: 173459-03-5
• Molecular Formula: C13H10ClN3O
• Molecular Weight: 259.695
• Hs Code.: 2933990090
• Mol file: 173459-03-5.mol

Synonyms:7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-6-(4-Methoxyphenyl)-;4-Chloro-6-(4-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyriMidine

Chemical Property of 7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-6-(4-Methoxyphenyl)-

Chemical Property:

• PSA: 50.80000
• LogP: 3.28690
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-6-(4-Methoxyphenyl)-

There total 4 articles about 7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-6-(4-Methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-hydroxy-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (173458-97-4) → 4-chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (173459-03-5)

Guidance literature:

With trichlorophosphate; for 2.5h; Reflux; Inert atmosphere;

DOI:10.1002/mrc.2560

Reference yield:

2-amino-3-carboxethyl-5-(4-methoxyphenyl)-pyrrole (173458-92-9) → 4-chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (173459-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: formic acid / N,N-dimethyl-formamide / 20 h / 150 °C

2.1: trichlorophosphate / 3 h / 90 °C

2.2: pH 12

With formic acid; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.10.012

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 4-chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (173459-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 0.33 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 60 °C

2.1: formic acid / N,N-dimethyl-formamide / 20 h / 150 °C

3.1: trichlorophosphate / 3 h / 90 °C

3.2: pH 12

With formic acid; sodium ethanolate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.10.012

upstream raw materials:

4-hydroxy-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine

2-amino-3-carboxethyl-5-(4-methoxyphenyl)-pyrrole

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

C₂₀H₁₇FN₄O

C₂₀H₁₇FN₄O

C₂₀H₁₇FN₄O

C₂₁H₁₉FN₄O