Methyl (2R,3S)-2-benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate

Base Information

Chemical Name:Methyl (2R,3S)-2-benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate
CAS No.:145451-91-8
Molecular Formula:C15H23NO4
Molecular Weight:281.352
Hs Code.:
Mol file:145451-91-8.mol

Synonyms:METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE;145451-91-8;METHYL (2R,3S)-2-(BENZYLAMINO)-3-HYDROXY-2-(HYDROXYMETHYL)-4-METHYLPENTANOATE;starbld0002328

Suppliers and Price of Methyl (2R,3S)-2-benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl(2R,3S)-2-Benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate
250mg
$ 1100.00

Medical Isotopes, Inc.
Methyl(2R,3S)-2-Benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate
50 mg
$ 1100.00

American Custom Chemicals Corporation
METHYL-(2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE 95.00%
5MG
$ 498.15

Total 2 raw suppliers

Chemical Property of Methyl (2R,3S)-2-benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate

Chemical Property:

Melting Point:66-67°C
PSA：78.79000
LogP:1.08810
Solubility.:Acetone, Dichloromethane, Ethyl Acetate, Methanol
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:281.16270821
Heavy Atom Count:20
Complexity:302

Purity/Quality:

99% ^*data from raw suppliers

Methyl(2R,3S)-2-Benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(CO)(C(=O)OC)NCC1=CC=CC=C1)O
Isomeric SMILES:CC(C)[C@@H]([C@](CO)(C(=O)OC)NCC1=CC=CC=C1)O
Uses Methyl (2R,3S)-2-Benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate (cas# 145451-91-8) is a compound useful in organic synthesis.

Technology Process of Methyl (2R,3S)-2-benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate

There total 8 articles about Methyl (2R,3S)-2-benzylamino-3-hydroxy-2-hydroxymethyl-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 145451-90-7
(2R,4R)-3-Benzyl-2-tert-butyl-4-((S)-1-hydroxy-2-methyl-propyl)-oxazolidine-4-carboxylic acid methyl ester

: 145451-91-8
(2R,3S)-2-Benzylamino-3-hydroxy-2-hydroxymethyl-4-methyl-pentanoic acid methyl ester

Guidance literature:: With trifluorormethanesulfonic acid; In methanol; at 80 ℃; for 6.5h;
DOI:10.1021/ja00052a096

Reference yield:

: 3-Benzyl-2-tert-butyl-oxazolidine-4-carboxylic acid methyl ester

: 145451-91-8
(2R,3S)-2-Benzylamino-3-hydroxy-2-hydroxymethyl-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / LDA, LiBr / tetrahydrofuran / 8 h / -78 °C

2: 91 percent / TfOH / methanol / 6.5 h / 80 °C

With trifluorormethanesulfonic acid; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/ja00052a096