3-(3-FURYL)ACRYLIC ACID

Base Information

• Chemical Name: 3-(3-FURYL)ACRYLIC ACID
• CAS No.: 81311-95-7
• Molecular Formula: C₇H₆O₃
• Molecular Weight: 138.123
• Mol file: 81311-95-7.mol

Synonyms:TIMTEC-BB SBB004191;RARECHEM BK HC S197;TRANS-3-FURANACRYLIC ACID;3-(3-FURYL)ACRYLIC ACID;trans-3-Furanacrylic acid 97%

Chemical Property of 3-(3-FURYL)ACRYLIC ACID

Chemical Property:

• Melting Point: 155-158 °C(lit.)
• Boiling Point: 261.4±15.0 °C(Predicted)
• PKA: 4.20±0.10(Predicted)
• PSA: 50.44000
• Density: 1.280±0.06 g/cm3(Predicted)
• LogP: 1.37740

Purity/Quality:

97% ^*data from raw suppliers

trans-3-Furanacrylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: trans-3-Furanacrylic acid was used in the detection of cis-urocanic acid in serum of mice by immunoassay.

Technology Process of 3-(3-FURYL)ACRYLIC ACID

There total 8 articles about 3-(3-FURYL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

furan-3-carboxaldehyde (498-60-2) + malonic acid (141-82-2) → (E)-3-furan-3-yl-acrylic acid (39244-10-5,81311-95-7)

Guidance literature:

With pyridine; at 90 ℃; for 2h;

DOI:10.1039/c0ob00487a

Reference yield: 91.0%

trans-3-furan-3-yl-acrylic acid ethyl ester (58963-70-5) → (E)-3-furan-3-yl-acrylic acid (39244-10-5,81311-95-7)

Guidance literature:

With potassium hydroxide; for 4h; Heating;

DOI:10.1002/chem.200501034

Reference yield:

Methyl 3-(3'-furanyl)prop-2-en-1-oate (99595-62-7) → (E)-3-furan-3-yl-acrylic acid (39244-10-5,81311-95-7)

Guidance literature:

With ethanol; water; lithium hydroxide; at 30 - 35 ℃; Inert atmosphere;

upstream raw materials:

furan-3-carboxaldehyde

malonic acid

trans-3-furan-3-yl-acrylic acid ethyl ester

furan-3-methanol

Downstream raw materials:

furo<2,3-c>pyridin-7(6H)-one

(E)-phenyl 3-(furan-3-yl)acrylate

4''-methoxyphenyl (E)-3-(3'-furyl)propenoate

7-Chlorofuro[2,3-c]pyridine