3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE

Base Information

• Chemical Name: 3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE
• CAS No.: 873056-62-3
• Molecular Formula: C₁₂H₉F₂N
• Molecular Weight: 205.207
• Hs Code.: 2921499090
• Mol file: 873056-62-3.mol

Synonyms:3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE;3',4'-Difluoro-biphenyl-2-amine

Chemical Property of 3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE

Chemical Property:

• Boiling Point: 306.8±27.0 °C(Predicted)
• PKA: 2.71±0.10(Predicted)
• PSA: 26.02000
• Density: 1.240±0.06 g/cm3(Predicted)
• LogP: 3.79520
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

3'',4''-Difluoro[1,1''-biphenyl]-2-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE

There total 8 articles about 3',4'-DIFLUORO[1,1'-BIPHENYL]-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-difluoro-2'-nitrobiphenyl (1202674-73-4) → 2-amino-3',4'-difluoro-1,1'-biphenyl (873056-62-3)

Guidance literature:

With hydrogen; nickel; In toluene; at 60 ℃; for 5h; under 2250.23 - 7500.75 Torr; Solvent; Temperature; Autoclave; Inert atmosphere;

Reference yield: 85.9%

1-bromo-3,4-difluorobenzene (348-61-8) + N-benzylidene-2-chloroaniline (884-29-7) → 2-amino-3',4'-difluoro-1,1'-biphenyl (873056-62-3)

Guidance literature:

1-bromo-3,4-difluorobenzene; With magnesium; In tetrahydrofuran; at 40 - 50 ℃; Inert atmosphere;

N-benzylidene-2-chloroaniline; With bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; at 70 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 70 ℃; for 3h;

Reference yield:

2-iodophenylamine (615-43-0) + (3,4-difluorophenyl)boronic acid (168267-41-2) → 2-amino-3',4'-difluoro-1,1'-biphenyl (873056-62-3)

Guidance literature:

With palladium diacetate; potassium carbonate; In water; acetone; at 65 ℃; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01300

upstream raw materials:

2-nitrophenyl bromide

3,4-difluoro-2'-nitrobiphenyl

(3,4-difluorophenyl)boronic acid

2-iodophenylamine

Refernces

• 1、 -. "Preparation method of fluorine-containing benzidine". Paragraph 0159-0163. . Retrieved 2018/07/30.
• 2、 Lai, Mei-Jung,Lee, Hsueh-Yun,Chuang, Hsun-Yueh,Chang, Li-Hsun,Tsai, An-Chi,Chen, Mei-Chuan,Huang, Han-Lin,Wu, Yi-Wen,Teng, Che-Ming,Pan, Shiow-Lin,Liu, Yi-Min,Mehndiratta, Samir,Liou, Jing-Ping. "N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling". . p. 6549 - 6558. Retrieved 2015/09/07.