4-(Thiazol-5-yl)aniline

Base Information

Chemical Name:4-(Thiazol-5-yl)aniline
CAS No.:332113-79-8
Molecular Formula:C9H8N2S
Molecular Weight:176.23822
Hs Code.:
European Community (EC) Number:854-360-6
Nikkaji Number:J1.524.690A
Mol file:332113-79-8.mol

Synonyms:4-(Thiazol-5-yl)aniline;332113-79-8;4-(1,3-thiazol-5-yl)aniline;SCHEMBL14320606;MFCD11934732;BS-50278;F75002;EN300-3017268

Suppliers and Price of 4-(Thiazol-5-yl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(Thiazol-5-yl)aniline 95+%
1g
$ 581.00

Chemenu
4-(thiazol-5-yl)aniline 95%
1g
$ 549.00

Alichem
4-(Thiazol-5-yl)aniline
10g
$ 3283.00

Alichem
4-(Thiazol-5-yl)aniline
5g
$ 2508.48

Total 3 raw suppliers

Chemical Property of 4-(Thiazol-5-yl)aniline

Chemical Property:

Melting Point:149.5-150.0 °C(Solv: water (7732-18-5))
Boiling Point:347.4±17.0 °C(Predicted)
PKA:3.68±0.10(Predicted)
PSA：67.15000
Density:1.261±0.06 g/cm3(Predicted)
LogP:2.97350
Storage Temp.:2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:176.04081944
Heavy Atom Count:12
Complexity:144

Purity/Quality:

99% ^*data from raw suppliers

4-(Thiazol-5-yl)aniline 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CN=CS2)N

Technology Process of 4-(Thiazol-5-yl)aniline

There total 7 articles about 4-(Thiazol-5-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 332113-79-8
5-(4-Aminophenyl)thiazole

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 12h; Inert atmosphere;

Reference yield: 63.0%

: 1086111-09-2
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1,3-thiazole

: 540-37-4
p-aminoiodobenzene

: 332113-79-8
5-(4-Aminophenyl)thiazole

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2009.05.013

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 332113-79-8
5-(4-Aminophenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; diethyl ether / 0.5 h / -78 °C

1.2: ZnCl₂ / hexane; diethyl ether / 0.5 h / -78 - 20 °C

1.3: Pd(PPh₃)4 / tetrahydrofuran / 24 h / Heating

2.1: 155 mg / aq. HCl

With hydrogenchloride; n-butyllithium; In diethyl ether; hexane; 1.3: Negishi cross-coupling reaction;
DOI:10.1055/s-2001-9753