[(3R)-1-methylpyrrolidin-3-yl]methanamine

Base Information

• Chemical Name: [(3R)-1-methylpyrrolidin-3-yl]methanamine
• CAS No.: 1207541-15-8
• Molecular Formula: C6H14N2
• Molecular Weight: 114.19
• Mol file: 1207541-15-8.mol

Synonyms:[(3R)-1-methylpyrrolidin-3-yl]methanamine;(R)-(1-Methylpyrrolidin-3-yl)methanamine;(R)-1-Methyl-3-(aminomethyl)pyrrolidine

Chemical Property of [(3R)-1-methylpyrrolidin-3-yl]methanamine

Chemical Property:

• Boiling Point: 134.7±8.0 °C(Predicted)
• PKA: 10.16±0.40(Predicted)
• PSA: 29.26000
• Density: 0.917±0.06 g/cm3(Predicted)
• LogP: 0.53500
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-Methyl-3-(aminomethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [(3R)-1-methylpyrrolidin-3-yl]methanamine

There total 1 articles about [(3R)-1-methylpyrrolidin-3-yl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

tert-butyl (R)-3-(aminomethyl)pyrrolidine-1-carboxylate (199174-29-3) → (R)-(1-methylpyrrolidin-3-yl)methanamine (1207541-15-8,1419075-98-1)

Guidance literature:

tert-butyl (R)-3-(aminomethyl)pyrrolidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

With water; sodium hydroxide; In tetrahydrofuran; for 0.166667h;

Reference yield:

(R)-(1-methylpyrrolidin-3-yl)methanamine (1207541-15-8,1419075-98-1) + C52H64N4O11 → C55H74N4O11

Guidance literature:

In water; acetonitrile; at 65 ℃; for 4h; Inert atmosphere;

Reference yield:

(R)-(1-methylpyrrolidin-3-yl)methanamine (1207541-15-8,1419075-98-1) + 4-(4-(3-(2-chlorophenyl)ureido)-1H-pyrazol-1-yl)thiophene-2-carboxylic acid → (R)-4-(4-(3-(2-chlorophenyl)ureido)-1H-pyrazol-1-yl)-N-((1-methylpyrrolidin-3-yl)methyl)thiophene-2-carboxamide

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃;

DOI:10.1021/acsmedchemlett.0c00533

upstream raw materials:

tert-butyl (R)-3-(aminomethyl)pyrrolidine-1-carboxylate

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