4-Isoxazolecarbonyl chloride, 5-cyclopropyl- (9CI)

Base Information

Chemical Name:4-Isoxazolecarbonyl chloride, 5-cyclopropyl- (9CI)
CAS No.:124845-05-2
Molecular Formula:C7H6ClNO2
Molecular Weight:171.583
Hs Code.:
Mol file:124845-05-2.mol

Synonyms:4-Isoxazolecarbonyl chloride, 5-cyclopropyl- (9CI)

Suppliers and Price of 4-Isoxazolecarbonyl chloride, 5-cyclopropyl- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-Isoxazolecarbonyl chloride, 5-cyclopropyl- (9CI)

Chemical Property:

Boiling Point:123-125 °C(Press: 13 Torr)
PKA:-4.23±0.50(Predicted)
PSA：43.10000
Density:1.431±0.06 g/cm3(Predicted)
LogP:1.93100

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Isoxazolecarbonyl chloride, 5-cyclopropyl- (9CI)

There total 3 articles about 4-Isoxazolecarbonyl chloride, 5-cyclopropyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124845-04-1
5-cyclopropylisoxazole-4-carboxylic acid

: 124845-05-2
5-cyclopropylisoxazole-4-carbonyl chloride

Guidance literature:: With thionyl chloride; at 50 ℃; for 2h;
DOI:10.1021/jm9604437

Reference yield:

: 32249-35-7
methyl 3-cyclopropyl-3-oxopropanoate

: 124845-05-2
5-cyclopropylisoxazole-4-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 20 h / 60 °C

1.2: 1.5 h / 60 °C

1.3: 4 h / 100 °C

2.1: oxalyl dichloride / dichloromethane / 0.5 h / 20 °C

With oxalyl dichloride; In dichloromethane;
DOI:10.1016/j.molstruc.2020.128628