1-Pyrrolidinecarboxylic acid, 2-[(carboxyMethoxy)Methyl]-, 1-(9H-fluoren-9-ylMethyl) ester, (2R)-

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 2-[(carboxyMethoxy)Methyl]-, 1-(9H-fluoren-9-ylMethyl) ester, (2R)-
• CAS No.: 1335206-44-4
• Molecular Formula: C22H23NO5
• Molecular Weight: 381.42172
• Hs Code.: 2933990090
• Mol file: 1335206-44-4.mol

Synonyms:1-Pyrrolidinecarboxylic acid, 2-[(carboxyMethoxy)Methyl]-, 1-(9H-fluoren-9-ylMethyl) ester, (2R)-;(R)-2-((1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)methoxy)acetic acid;(2R)-2-[(Carboxymethoxy)methyl]-1-pyrrolidinecarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(carboxyMethoxy)Methyl]-, 1-(9H-fluoren-9-ylMethyl) ester, (2R)-

Chemical Property:

• PSA: 76.07000
• LogP: 3.43900
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2R)-2-[(Carboxymethoxy)Methyl]-1-pyrrolidinecarboxylicAcid1-(9h-Fluoren-9-Ylmethyl)Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(carboxyMethoxy)Methyl]-, 1-(9H-fluoren-9-ylMethyl) ester, (2R)-

There total 3 articles about 1-Pyrrolidinecarboxylic acid, 2-[(carboxyMethoxy)Methyl]-, 1-(9H-fluoren-9-ylMethyl) ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(9H-fluoren-9-yl)methyl 2-((2-tert-butoxy-2-oxoethoxy)methyl)pyrrolidine-1-carboxylate → 1,2-((1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)methoxy)acetic acid (1335206-44-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

Reference yield:

1-(tert-butoxycarbonyl)prolin-2R-ol (59378-81-3,69610-40-8,83435-58-9) → 1,2-((1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)methoxy)acetic acid (1335206-44-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide; tetra-(n-butyl)ammonium iodide / toluene

2: trifluoroacetic acid / dichloromethane

3: N-ethyl-N,N-diisopropylamine / dichloromethane

4: trifluoroacetic acid; triethylsilane / dichloromethane

With triethylsilane; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; toluene;

DOI:10.1002/pep2.24199

Reference yield:

(R)-tert-butyl 2-((2-(tert-butoxy)-2-oxoethoxy)methyl)pyrrolidine-1-carboxylate (1018826-65-7) → 1,2-((1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)methoxy)acetic acid (1335206-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: trifluoroacetic acid; triethylsilane / dichloromethane

With triethylsilane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/pep2.24199

upstream raw materials:

1-(tert-butoxycarbonyl)prolin-2R-ol

(R)-tert-butyl 2-((2-(tert-butoxy)-2-oxoethoxy)methyl)pyrrolidine-1-carboxylate

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