Isoquinolin-3-ylMethanaMine hydrochloride

Base Information

• Chemical Name: Isoquinolin-3-ylMethanaMine hydrochloride
• CAS No.: 1628557-04-9
• Molecular Formula: C₁₀H₁₀N₂*2ClH
• Molecular Weight: 231.125
• Mol file: 1628557-04-9.mol

Synonyms:Isoquinolin-3-ylMethanaMine hydrochloride

Chemical Property of Isoquinolin-3-ylMethanaMine hydrochloride

Chemical Property:

• PSA: 38.91000
• LogP: 3.19580
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Isoquinolin-3-ylmethanaminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoquinolin-3-ylMethanaMine hydrochloride

There total 5 articles about Isoquinolin-3-ylMethanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-cyanoisoquinoline (26947-41-1) → 3-(aminomethyl)isoquinoline dihydrochloride (1628557-04-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 2h; under 1551.4 Torr; Ambient temperature;

Reference yield:

isoquinoline-3(S)-carboxamide (50458-77-0) → 3-(aminomethyl)isoquinoline dihydrochloride (1628557-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / triethylamine, trifluoroacetic anhydride / CH₂Cl₂ / 0.03 h / 0 °C

2: 65 percent / H₂, HCl / 10percent Pd/C / methanol / 2 h / 1551.4 Torr / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (67123-97-1) → 3-(aminomethyl)isoquinoline dihydrochloride (1628557-04-9)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂SO₄

2: Pd/C / xylene / Heating

3: 98 percent / methanolic NH₃ / Ambient temperature

4: 92 percent / triethylamine, trifluoroacetic anhydride / CH₂Cl₂ / 0.03 h / 0 °C

5: 65 percent / H₂, HCl / 10percent Pd/C / methanol / 2 h / 1551.4 Torr / Ambient temperature

With hydrogenchloride; palladium on activated charcoal; sulfuric acid; ammonia; hydrogen; triethylamine; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; dichloromethane; xylene;

upstream raw materials:

3-cyanoisoquinoline

isoquinoline-3(S)-carboxamide

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid