50458-77-0 Usage
Uses
Used in Pharmaceutical Development:
Isoquinoline-3-carboxamide is used as a lead compound in drug development for its ability to modulate neurotransmitter receptors and ion channels in the central nervous system. This makes it a potential candidate for the treatment of various neurological disorders.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, Isoquinoline-3-carboxamide is used as an antimicrobial agent, potentially effective against a range of bacterial and fungal infections.
Used in Antitumor Applications:
Isoquinoline-3-carboxamide is used as an antitumor agent, exhibiting potential in the treatment of various types of cancer due to its ability to target and inhibit tumor growth.
Used in Neurodegenerative Disease Treatment:
In the field of neurodegenerative diseases, Isoquinoline-3-carboxamide is used as a therapeutic agent for conditions such as Parkinson's and Alzheimer's disease, leveraging its potential neuroprotective and disease-modifying properties.
Used in Research:
Isoquinoline-3-carboxamide is utilized in scientific research to explore its diverse biological activities and to understand its mechanisms of action, which can contribute to the advancement of knowledge in pharmacology and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 50458-77-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,4,5 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 50458-77:
(7*5)+(6*0)+(5*4)+(4*5)+(3*8)+(2*7)+(1*7)=120
120 % 10 = 0
So 50458-77-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2O/c11-10(13)9-5-7-3-1-2-4-8(7)6-12-9/h1-6H,(H2,11,13)
50458-77-0Relevant academic research and scientific papers
Interconversion of nitrenes, azirenes, and diradicals: Rearrangement of 3-isoquinolylnitrene to o-cyanophenylketenimine and 1-cyanoisoindole
Vosswinkel, Michael,Lueerssen, Holger,Kvaskoff, David,Wentrup, Curt
body text, p. 1171 - 1178 (2009/07/25)
Photolysis of tetrazolo[1,5-b]isoquinoline/3-azidoisoquinoline 22T/22A generates 3-isoquinolylnitrene 23, which has been characterized together with a diradical species (25) by Ar matrix ESR spectroscopy. Photolysis at λ > 300 nm generates azirene 24, characterized by IR spectroscopy, whereas further broadband UV photolysis destroys the azirene to produce o-cyanophenylketenimine 17. The use of 15N-labeled tetrazole/azide 22T′/22A′ demonstrates rapid equilibration of two regioisomeric 15N-labeled azirenes 24′ and 24″ prior to formation of 17. Flash vacuum thermolysis (FVT) of 22T/22A affords 1-cyano-2H-isoindole 27 in quantitative yield. FVT of 15N-labeled tetrazole/azide 22T′/22A′ causes scrambling of 15N label in the 1-cyano-2H-isoindole product. It is concluded that the interconversion of azirenes 24 takes place via the unobserved diazacycloheptatetraene/ diazacycloheptatrienylidene 32/33, and that the rearrangement of azirene to ketenimine 17 and 1-cyanoisoindole 27 takes place via reversion to nitrene 23 followed by ring opening to diradical 25.
Synthesis of carbamoylpyridine and imidazo[1,5-a]pyridin-1,3-diones via ortho-acetalhydantoin intermediates
Chezal, Jean M.,Moreau, Emmanuel,Desbois, Nicolas,Blache, Yves,Chavignon, Olivier,Teulade, Jean C.
, p. 553 - 556 (2007/10/03)
A new method for preparing carbamoylpyridine and imidazo[1,5-a]pyridin-1,3- dione rings from an ortho-acetalmethylideneimidazolidin-2,4-dione is described.
