2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95%

Base Information

• Chemical Name: 2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95%
• CAS No.: 127792-45-4
• Molecular Formula: C₁₄H₁₀BrClNO₂*Na
• Molecular Weight: 362.586
• Mol file: 127792-45-4.mol

Synonyms:2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95%;Diclofenac BroMide SodiuM Salt;Diclofenac MonobroMo IMpurity, SodiuM Salt;Diclofenac IMpurity D;Diclofenac MonobroMo SodiuM Salt IMpurity;Diclofenac IMpurity-D(EP/BP);Diclofenac EP Impurity D

Chemical Property of 2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95%

Chemical Property:

• PSA: 52.16000
• LogP: 3.21150

Purity/Quality:

99.90% ^*data from raw suppliers

DiclofenacMonobromoSodiumSaltImpurity ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diclofenac (D436450) bromide impurity. Diclofenac impurity D.

Technology Process of 2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95%

There total 3 articles about 2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-Bromo-6-chloro-phenyl)-1,3-dihydro-indol-2-one (1219112-85-2) → Sodium; [2-(2-bromo-6-chloro-phenylamino)-phenyl]-acetate (127792-45-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 4h; Yield given; Heating;

DOI:10.1021/jm00171a008

Reference yield:

(2-Bromo-6-chloro-phenyl)-phenyl-amine (123790-84-1) → Sodium; [2-(2-bromo-6-chloro-phenylamino)-phenyl]-acetate (127792-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 16 h / Heating

2: AlCl₃ / 2 h / 160 °C

3: 2 N NaOH / ethanol; H₂O / 4 h / Heating

With sodium hydroxide; aluminium trichloride; In ethanol; water;

DOI:10.1021/jm00171a008

Reference yield:

N-(2-Bromo-6-chloro-phenyl)-2-chloro-N-phenyl-acetamide → Sodium; [2-(2-bromo-6-chloro-phenylamino)-phenyl]-acetate (127792-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / 2 h / 160 °C

2: 2 N NaOH / ethanol; H₂O / 4 h / Heating

With sodium hydroxide; aluminium trichloride; In ethanol; water;

DOI:10.1021/jm00171a008

upstream raw materials:

1-(2-Bromo-6-chloro-phenyl)-1,3-dihydro-indol-2-one

(2-Bromo-6-chloro-phenyl)-phenyl-amine

Refernces