Methoxy-X04

Base Information

• Chemical Name: Methoxy-X04
• CAS No.: 863918-78-9
• Molecular Formula: C23H20O3
• Molecular Weight: 344.4031
• Mol file: 863918-78-9.mol

Synonyms:Methoxy-X04

Chemical Property of Methoxy-X04

Chemical Property:

• PSA: 49.69000
• LogP: 5.44720
• Solubility.: Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

Methoxy-X04 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer''s disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.
• Uses: Methoxy-X04 is a small molecule Aβ-binding agent, which exhibits anti-amyloid effects.

Technology Process of Methoxy-X04

There total 5 articles about Methoxy-X04 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-bis(bromomethyl)-2-methoxybenzene (46045-95-8) → (E,E)-1-methoxy-2,5-bis(4-hydroxy)styrylbenzene (863918-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 16 h / 150 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; mineral oil; 1.1: |Arbuzov Reaction / 2.2: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1016/j.bmc.2014.02.054

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (E,E)-1-methoxy-2,5-bis(4-hydroxy)styrylbenzene (863918-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; 2.2: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1016/j.bmc.2014.02.054

Reference yield:

2,5-Dimethyl-anisol (1706-11-2) → (E,E)-1-methoxy-2,5-bis(4-hydroxy)styrylbenzene (863918-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Inert atmosphere; Reflux

2.1: 16 h / 150 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; mineral oil; 2.1: |Arbuzov Reaction / 3.2: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1016/j.bmc.2014.02.054

upstream raw materials:

1,4-bis(bromomethyl)-2-methoxybenzene

4-hydroxy-benzaldehyde

2,5-Dimethyl-anisol

tetraethyl ((2-methoxy-1,4-phenylene)bis(methylene))bis(phosphonate)

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