methyl 4-(3,5-dimethoxyphenyl)-1-(tetrahydrofuran-2-yl)-1H-imidazole-2-carboxylate

Base Information

Chemical Name:methyl 4-(3,5-dimethoxyphenyl)-1-(tetrahydrofuran-2-yl)-1H-imidazole-2-carboxylate
CAS No.:188199-83-9
Molecular Formula:C₁₇H₂₀N₂O₅
Molecular Weight:0
Hs Code.:

Synonyms:methyl 4-(3,5-dimethoxyphenyl)-1-(tetrahydrofuran-2-yl)-1H-imidazole-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(3,5-dimethoxyphenyl)-1-(tetrahydrofuran-2-yl)-1H-imidazole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of methyl 4-(3,5-dimethoxyphenyl)-1-(tetrahydrofuran-2-yl)-1H-imidazole-2-carboxylate

There total 3 articles about methyl 4-(3,5-dimethoxyphenyl)-1-(tetrahydrofuran-2-yl)-1H-imidazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1191-99-7,75454-45-4
2,3-dihydro-2H-furan

: 188199-81-7
2-carbomethoxy-4⁽⁵⁾-(3',5'-dimethoxyphenyl)imidazole

: 188199-83-9
1-(2'-tetrahydrofuranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; at 50 ℃; for 2h;
DOI:10.1021/jo981805g

Reference yield:

: 39151-19-4
1-(3,5-dimethoxyphenyl)ethan-1-one

: 188199-83-9
1-(2'-tetrahydrofuranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / aq. HBr / dimethylsulfoxide / 8 h / 60 - 68 °C

2: 63 percent / NH₄OAc / acetonitrile / 2 h / 0 °C

3: 82 percent / p-TsOH*H₂O / tetrahydrofuran / 2 h / 50 °C

With ammonium acetate; hydrogen bromide; toluene-4-sulfonic acid; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo981805g

Reference yield:

: 188199-78-2
3',5'-dimethoxyphenylglyoxal monohydrate

: 188199-83-9
1-(2'-tetrahydrofuranyl)-2-carbomethoxy-4⁽⁵⁾-(3'',5''-dimethoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NH₄OAc / acetonitrile / 2 h / 0 °C

2: 82 percent / p-TsOH*H₂O / tetrahydrofuran / 2 h / 50 °C

With ammonium acetate; toluene-4-sulfonic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo981805g