tert-butyl (4-bromophenyl)methylcarbamate(SALTDATA: FREE)

Base Information

• Chemical Name: tert-butyl (4-bromophenyl)methylcarbamate(SALTDATA: FREE)
• CAS No.: 639520-70-0
• Molecular Formula: C12H16BrNO2
• Molecular Weight: 286.169
• Hs Code.: 2924299090
• Mol file: 639520-70-0.mol

Synonyms:tert-butyl (4-bromophenyl)methylcarbamate(SALTDATA: FREE);N-BOC 4-Bromo-N-methylaniline;tert-Butyl N-(4-bromophenyl)-N-methylcarbamate;tert-Butyl (4-broMophenyl)(Methyl)carbaMate

Chemical Property of tert-butyl (4-bromophenyl)methylcarbamate(SALTDATA: FREE)

Chemical Property:

• PSA: 29.54000
• LogP: 3.82040
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Boc4-Bromo-N-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (4-bromophenyl)methylcarbamate(SALTDATA: FREE)

There total 7 articles about tert-butyl (4-bromophenyl)methylcarbamate(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-bromo-N-methylaniline (6911-87-1,211060-12-7) → 4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide (639520-70-0)

Guidance literature:

In ethanol; at 20 ℃; for 70h;

DOI:10.1055/s-0031-1290899

Reference yield:

tert-butyl (4-bromophenyl)carbamate (131818-17-2) + methyl iodide (74-88-4) → 4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide (639520-70-0)

Guidance literature:

tert-butyl (4-bromophenyl)carbamate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at 20 ℃;

With phosphoric acid; In tetrahydrofuran; water;

Reference yield:

N-(4-bromophenyl)-N,4-dimethylbenzenesulfonamide (32857-49-1) → 4-(N-tert-butyloxycarbonyl-N-methylamino)phenyl bromide (639520-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium diphenylphosphine / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 12 h / Inert atmosphere

With potassium diphenylphosphine; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/ja309642r

upstream raw materials:

tert-butyl (4-bromophenyl)carbamate

methyl iodide

di-tert-butyl dicarbonate

4-bromo-N-methylaniline

Downstream raw materials:

tert-butyl 4-((5R,11R,13S,17S)-5,17-dihydroxy-13-methyl-17-prop-1-ynyl-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-11-yl)phenyl(methyl)carbamate

(11β,16α,17α)-17-hydroxy-16-methyl-11-(4-(methylamino)phenyl)-17-prop-1-ynylestra-4,9-dien-3-one

methyl 4-[(tert-butoxycarbonyl)(methyl)amino]benzoate

C₁₆H₂₅BN₂O₄

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