rac N-Acetyl Ephedrine

Base Information

• Chemical Name: rac N-Acetyl Ephedrine
• CAS No.: 5661-42-7
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 5661-42-7.mol

Synonyms:rac N-Acetyl Ephedrine;(R*,S*)-N-(2-Hydroxy-1-Methyl-2-phenylethyl)-N-MethylacetaMide;erythro-N-(β-Hydroxy-α-Methylphenethyl)-N-MethylacetaMide

Chemical Property of rac N-Acetyl Ephedrine

Chemical Property:

• Boiling Point: 361.2±35.0 °C(Predicted)
• PKA: 13.52±0.20(Predicted)
• PSA: 40.54000
• Density: 1.083±0.06 g/cm3(Predicted)
• LogP: 1.58680
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

racN-AcetylEphedrine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An acetylated derivative of the α- and β-Adrenergic agonist Ephedrine (E575000).

Technology Process of rac N-Acetyl Ephedrine

There total 6 articles about rac N-Acetyl Ephedrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

rac-pseudoephedrine (90-82-4,299-42-3,321-97-1,321-98-2,4125-58-0,34783-90-9,38732-95-5,53214-57-6,90-81-3,7009-81-6,90-83-5,6912-63-6) + acetic anhydride (108-24-7) → N-((1RS,2RS)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide (2272-83-5,5661-42-7,5878-95-5,14593-17-0,16413-75-5,52305-20-1,84472-25-3,144071-23-8)

Guidance literature:

With sodium hydrogencarbonate; 1) 70 deg C, 10 min, 2) H₂O, 1.5 h;

Reference yield: 60.0%

ephedrine (90-81-3,7009-81-6,90-83-5,6912-63-6) + acetic anhydride (108-24-7) → N-((1RS,2SR)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide (2272-83-5,5661-42-7,5878-95-5,14593-17-0,16413-75-5,52305-20-1,84472-25-3,144071-23-8)

Guidance literature:

With sodium hydrogencarbonate; 1) 70 deg C, 10 min, 2) H₂O, 1.5 h;

Reference yield:

(1RS:2SR)-2-methylamino-1-acetoxy-1-phenyl-propane; hydrochloride (1630-34-8,14383-62-1,95469-47-9) → N-((1RS,2SR)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide (2272-83-5,5661-42-7,5878-95-5,14593-17-0,16413-75-5,52305-20-1,84472-25-3,144071-23-8)

Guidance literature:

With alkaline solution;

DOI:10.1021/ja01193a036

upstream raw materials:

rac-pseudoephedrine

acetic anhydride

N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

ephedrine

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