1-Hydrazinopyridazino(4,5-b)quinoxaline

Base Information

• Chemical Name: 1-Hydrazinopyridazino(4,5-b)quinoxaline
• CAS No.: 95631-24-6
• Molecular Formula: C₁₀H₈N₆
• Molecular Weight: 212.214
• DSSTox Substance ID: DTXSID10914902
• Wikidata: Q82885751
• Mol file: 95631-24-6.mol

Synonyms:1-Hydrazinopyridazino(4,5-b)quinoxaline;95631-24-6;pyridazino[4,5-b]quinoxalin-4-ylhydrazine;BRN 4459583;Pyridazino(4,5-b)quinoxaline, 1-hydrazino-;1-HYDRAZINYLPYRIDAZINO[4,5-B]QUINOXALINE;Pyridazino(4,5-b)quinoxalin-1(2H)-one, hydrazone;DTXSID10914902

Chemical Property of 1-Hydrazinopyridazino(4,5-b)quinoxaline

Chemical Property:

• PSA: 89.61000
• LogP: 1.63190
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 212.08104428
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

1-hydrazinyl-Pyridazino[4,5-b]quinoxaline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)N=C3C=NN=C(C3=N2)NN

Technology Process of 1-Hydrazinopyridazino(4,5-b)quinoxaline

There total 8 articles about 1-Hydrazinopyridazino(4,5-b)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,2-Dihydro-1-thiocarbonylpyridazino<4,5-b>quinoxaline (95631-23-5) → 1-Hydrazinopyridazino<4,5-b>quinoxaline (95631-24-6)

Guidance literature:

With hydrazine; In ethanol; for 4h; Heating;

DOI:10.1002/jhet.5570210505

Reference yield:

benzofurazan oxide (480-96-6,68100-26-5) → 1-Hydrazinopyridazino<4,5-b>quinoxaline (95631-24-6)

Guidance literature:

Multi-step reaction with 5 steps

1: morpholine / 10 h

2: Cl₂ / acetic acid / 80 - 85 °C

3: 90 percent hydrazine hydrate / ethanol; H₂O / 24 h / Ambient temperature

4: phosphorus pentasulfide / pyridine / 6 h / Heating

5: hydrazine / ethanol / 4 h / Heating

With diphosphorus pentasulfide; chlorine; hydrazine hydrate; hydrazine; morpholine; In pyridine; ethanol; water; acetic acid;

Reference yield:

2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide (13297-18-2) → 1-Hydrazinopyridazino<4,5-b>quinoxaline (95631-24-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Cl₂ / acetic acid / 80 - 85 °C

2: 90 percent hydrazine hydrate / ethanol; H₂O / 24 h / Ambient temperature

3: phosphorus pentasulfide / pyridine / 6 h / Heating

4: hydrazine / ethanol / 4 h / Heating

With diphosphorus pentasulfide; chlorine; hydrazine hydrate; hydrazine; In pyridine; ethanol; water; acetic acid;

upstream raw materials:

1,2-Dihydro-1-thiocarbonylpyridazino<4,5-b>quinoxaline

1,2-Dihydro-1-oxopyridazino<4,5-b>quinoxaline

benzofurazan oxide

2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide

Downstream raw materials:

3-Phenyl-1,2,3a,4,6,11-hexaaza-cyclopenta[a]anthracene

N-[1-Phenyl-eth-(E)-ylidene]-N'-(2,3,9,10-tetraaza-anthracen-1-yl)-hydrazine

1-<2-(phenylmethylene)hydrazino>pyridazino<4,5-b>quinoxaline

N-(2,3,9,10-Tetraaza-anthracen-1-yl)-N'-[1-p-tolyl-meth-(E)-ylidene]-hydrazine

Refernces

• 1、 Monge Vega,Gil,Fernandez-Alvarez. "Synthesis of 1-hydrazinopyridazino[4,5-b]quinoxaline and related compounds". . p. 1271 - 1276. Retrieved 2007/10/02.