1S,2S-N-[3,5-bis(trifluoromethyl)]benzene sulfonamide-1,2-diphenyl ethylenediamine

Base Information

• Chemical Name: 1S,2S-N-[3,5-bis(trifluoromethyl)]benzene sulfonamide-1,2-diphenyl ethylenediamine
• CAS No.: 313342-22-2
• Molecular Formula: C22H18F6N2O2S
• Molecular Weight: 488.45
• Mol file: 313342-22-2.mol

Synonyms:1S,2S-N-[3,5-bis(trifluoromethyl)]benzene sulfonamide-1,2-diphenyl ethylenediamine;N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluorom ethyl)benzenesulfonamide

Chemical Property of 1S,2S-N-[3,5-bis(trifluoromethyl)]benzene sulfonamide-1,2-diphenyl ethylenediamine

Chemical Property:

• PSA: 80.57000
• LogP: 7.61580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1S,2S-N-[3,5-bis(trifluoromethyl)]benzene sulfonamide-1,2-diphenyl ethylenediamine

There total 1 articles about 1S,2S-N-[3,5-bis(trifluoromethyl)]benzene sulfonamide-1,2-diphenyl ethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S,S)-1,2-diphenyl-1,2-diaminoethane (29841-69-8) + 3,5-bis(trifluoromethyl)benzenesulfonyl chloride (39234-86-1) → N-((1S,2S)-2-amino-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide (313342-22-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h; Cooling with ice;

DOI:10.1039/c0ob00757a

Reference yield: 84.0%

N-((1S,2S)-2-amino-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide (313342-22-2) + (2S,4S,8R)-2-((S)-isothiocyanato(6-methoxyquinolin-4-yl)methyl)-8-vinylquinuclidine (1295509-64-6) → N-((1S,2S)-2-(3-((S)-(6-methoxyquinolin-4-yl)-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thioureido)-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide (1295509-68-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c0ob00757a

Reference yield: 69.0%

N-((1S,2S)-2-amino-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide (313342-22-2) + (1S,2S,5R)-2-((R)-isothiocyanato-(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine (1416881-86-1) → N-((1S,2S)-2-(3-((R)-(6-methoxyquinolin-4-yl)-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thioureido)-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Guidance literature:

In tetrahydrofuran; for 3h; Reflux;

DOI:10.1002/anie.201303572

upstream raw materials:

(S,S)-1,2-diphenyl-1,2-diaminoethane

3,5-bis(trifluoromethyl)benzenesulfonyl chloride

Downstream raw materials:

N-((1S,2S)-2-(3-((S)-(6-methoxyquinolin-4-yl)-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thioureido)-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

N-((1S,2S)-2-(3-((S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thioureido)-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

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