2-(BROMOMETHYL)-2,6-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(3H)-ONE

Base Information

• Chemical Name: 2-(BROMOMETHYL)-2,6-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(3H)-ONE
• CAS No.: 139047-54-4
• Molecular Formula: C11H10BrN3O
• Molecular Weight: 280.124
• Hs Code.: 2933990090
• Mol file: 139047-54-4.mol

Synonyms:2-(BROMOMETHYL)-2,6-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(3H)-ONE

Chemical Property of 2-(BROMOMETHYL)-2,6-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(3H)-ONE

Chemical Property:

• Melting Point: 213-215°
• PSA: 50.15000
• LogP: 0.44300

Purity/Quality:

98%min ^*data from raw suppliers

2-(Bromomethyl)-2,6-dihydroimidazo[1,2-c]-quinazolin-5(3H)-one >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(BROMOMETHYL)-2,6-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(3H)-ONE

There total 3 articles about 2-(BROMOMETHYL)-2,6-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(3H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-dihydro-4-imino-2-allylquinazolin-2(1H)-one (122372-31-0) → 2-bromomethyl-2,3-dihydroimidazo[1,2-c ]quinazolin-5(6H)-one (139047-54-4)

Guidance literature:

With N-Bromosuccinimide; In water;

Reference yield:

2-(3-allylureido)benzonitrile (122372-27-4) → 2-bromomethyl-2,3-dihydroimidazo[1,2-c ]quinazolin-5(6H)-one (139047-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 28percent aq. NH₃ / ethanol / 0.25 h / Heating

2: 95 percent / NBS / tetrahydrofuran / 0.42 h / Ambient temperature

With ammonium hydroxide; N-Bromosuccinimide; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00067a017

Reference yield:

anthranilic acid nitrile (1885-29-6) → 2-bromomethyl-2,3-dihydroimidazo[1,2-c ]quinazolin-5(6H)-one (139047-54-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 48 h / Ambient temperature

2: 84 percent / 28percent aq. NH₃ / ethanol / 0.25 h / Heating

3: 95 percent / NBS / tetrahydrofuran / 0.42 h / Ambient temperature

With ammonium hydroxide; N-Bromosuccinimide; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00067a017

upstream raw materials:

3,4-dihydro-4-imino-2-allylquinazolin-2(1H)-one

2-(3-allylureido)benzonitrile

anthranilic acid nitrile

Downstream raw materials:

AT 112

2-<(4-benzylpiperazin-1-yl)methyl>-2,3-dihydroimidazo<1,2-c>quinazolin-5(6H)-one

DL 028

2-<<4-(4-fluorophenyl)piperazin-1-yl>methyl>-2,3-dihydroimidazo<1,2-c>quinazolin-5(6H)-one