3-(trifluoroMethyl)azetidin-3-olHCL

Base Information

• Chemical Name: 3-(trifluoroMethyl)azetidin-3-olHCL
• CAS No.: 848392-24-5
• Molecular Formula: C4H7ClF3NO
• Molecular Weight: 177.5526896
• Mol file: 848392-24-5.mol

Synonyms:3-(trifluoroMethyl)azetidin-3-olHCL;3-(Trifluoromethyl)-3-azetidinol;3-Azetidinol,3-(trifluoromethyl)-

Chemical Property of 3-(trifluoroMethyl)azetidin-3-olHCL

Chemical Property:

• PSA: 32.26000
• LogP: 0.21180

Purity/Quality:

97% ^*data from raw suppliers

3-(Trifluoromethyl)azetidin-3-ol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(trifluoroMethyl)azetidin-3-olHCL

There total 1 articles about 3-(trifluoroMethyl)azetidin-3-olHCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) + (trifluoromethyl)trimethylsilane (81290-20-2) → 3-hydroxy-3-trifluoromethylazetidine (848392-24-5)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; at 5 - 20 ℃; for 4h;

Reference yield: 57.0%

(±) 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid + 3-hydroxy-3-trifluoromethylazetidine (848392-24-5) → (±)-8-cyclohexyl-N-[(dimethylamino)sulfonyl]-1,1a,2,12btetrahydro-1a-[(3-hydroxy-3-trifluoromethyl-1-azetidinyl)carbonyl]-11-methoxycycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:

(±) 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃;

3-hydroxy-3-trifluoromethylazetidine; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1021/jm4016894

Reference yield:

3-hydroxy-3-trifluoromethylazetidine (848392-24-5) + 4-nitrophenyl 4-((1-(3-chloro-4-(dimethylcarbamoyl)phenyl)piperidin-4-yl)oxy)piperidine-1-carboxylate → 2-chloro-4-(4-((1-(3-hydroxy-3-(trifluoromethyl)azetidine-1-carbonyl)piperidin-4-yl)oxy)piperidin-1-yl)-N.N-dimethylbenzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 120 ℃; for 1h; Microwave irradiation;

upstream raw materials:

tert-butyl 3-oxoazetidine-1-carboxylate

(trifluoromethyl)trimethylsilane