Benzyl 1,3-dihydro-5-(hydroxymethyl)-2H-isoindole-2-carboxylate, 2-[(Benzyloxy)carbonyl]-5-(hydroxymethyl)isoindoline

Base Information

Chemical Name:Benzyl 1,3-dihydro-5-(hydroxymethyl)-2H-isoindole-2-carboxylate, 2-[(Benzyloxy)carbonyl]-5-(hydroxymethyl)isoindoline
CAS No.:1019889-84-9
Molecular Formula:C17H17NO3
Molecular Weight:283.327
Hs Code.:2933998090
Mol file:1019889-84-9.mol

Synonyms:1,3-Dihydro-5-(hydroxymethyl)-2H-isoindole, N-CBZ protected;Benzyl 1,3-dihydro-5-(hydroxymethyl)-2H-isoindole-2-carboxylate, 2-[(Benzyloxy)carbonyl]-5-(hydroxymethyl)isoindoline;5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Suppliers and Price of Benzyl 1,3-dihydro-5-(hydroxymethyl)-2H-isoindole-2-carboxylate, 2-[(Benzyloxy)carbonyl]-5-(hydroxymethyl)isoindoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Benzyl 1,3-dihydro-5-(hydroxymethyl)-2H-isoindole-2-carboxylate, 2-[(Benzyloxy)carbonyl]-5-(hydroxymethyl)isoindoline

Chemical Property:

PSA：49.77000
LogP:2.76920

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzyl 1,3-dihydro-5-(hydroxymethyl)-2H-isoindole-2-carboxylate, 2-[(Benzyloxy)carbonyl]-5-(hydroxymethyl)isoindoline

There total 3 articles about Benzyl 1,3-dihydro-5-(hydroxymethyl)-2H-isoindole-2-carboxylate, 2-[(Benzyloxy)carbonyl]-5-(hydroxymethyl)isoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 120942-75-8
benzyl N,N-bis(prop-2-yn-1-yl)carbamate

: 107-19-7
propargyl alcohol

: 1019889-84-9
5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Guidance literature:: Wilkinson's catalyst; In toluene; at 55 - 65 ℃; for 1h; Product distribution / selectivity;

Reference yield: 98.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 127168-98-3
5-hydroxymethyl-2,3-dihydro-1H-isoindole

: 1019889-84-9
5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 1019889-84-9
5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / water; ethyl acetate / 0 - 20 °C

2: Wilkinson's catalyst / toluene / 2.5 h / 50 - 100 °C

With potassium carbonate; Wilkinson's catalyst; In water; ethyl acetate; toluene;