5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Base Information

Chemical Name:5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester
CAS No.:1019889-91-8
Molecular Formula:C₁₈H₁₉NO₅S
Molecular Weight:361.419
Hs Code.:
Mol file:1019889-91-8.mol

Synonyms:5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Suppliers and Price of 5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

There total 1 articles about 5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1019889-84-9
5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

: 124-63-0
methanesulfonyl chloride

: 1019889-91-8
5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Guidance literature:: 5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester; methanesulfonyl chloride; With triethylamine; In tetrahydrofuran; ethyl acetate; at 0 - 12 ℃; for 3h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate; for 0.333333h; Product distribution / selectivity;

Reference yield: 65.0%

: 109-01-3
1-methyl-piperazine

: 1019889-91-8
5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

: 5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester dihydrochloride salt

Guidance literature:: 1-methyl-piperazine; 5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester; With potassium carbonate; In acetone; at 15 - 17 ℃; for 3.75h;

With hydrogenchloride; In methanol; at 0 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 47.0%

: 109-01-3
1-methyl-piperazine

: 1019889-91-8
5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

: 1019890-05-1
5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester

Guidance literature:: 1-methyl-piperazine; 5-methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester; In dichloromethane; at 20 - 30 ℃; for 1h;

With hydrogenchloride; In water;

With sodium hydroxide; In water; pH=10 - 11; Product distribution / selectivity;