Ixazomib citrate (USAN)

Base Information

• Chemical Name: Ixazomib citrate (USAN)
• CAS No.: 1239908-20-3
• Molecular Formula: C20H23BCl2N2O9
• Molecular Weight: 517.12

Synonyms:Ixazomib citrate (USAN);2-[(1R)-1-[[2-[(2,5-Dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diacetic acid

Chemical Property of Ixazomib citrate (USAN)

Chemical Property:

• Appearance/Colour: White to off-white solid powder
• PKA: 3.59±0.10(Predicted)
• PSA: 168.33000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 2.74480

Purity/Quality:

99% ^*data from raw suppliers

IxazomibCitrate(MLN-9708) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ixazomib citrate (USAN)

There total 29 articles about Ixazomib citrate (USAN) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Ixazomib (1072833-77-2) + citric acid (77-92-9,906507-37-7) → 2,2’-{2-[(1R)-1-({[(2,5-dichlorobenzoyl)amino]acetyl}amino)-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid (1239908-20-3)

Guidance literature:

In acetone; at 20 ℃; for 0.5h;

Reference yield: 94.0%

C21H31BCl2N2O4 + citric acid (77-92-9,906507-37-7) → 2,2’-{2-[(1R)-1-({[(2,5-dichlorobenzoyl)amino]acetyl}amino)-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid (1239908-20-3)

Guidance literature:

In ethyl acetate; at 50 - 70 ℃; for 24h; Solvent;

Reference yield: 93.0%

(R)-2,5-dichloro-N-(2-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)2-oxoethyl)benzamide + citric acid (77-92-9,906507-37-7) → 2,2’-{2-[(1R)-1-({[(2,5-dichlorobenzoyl)amino]acetyl}amino)-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid (1239908-20-3)

Guidance literature:

In ethyl acetate; at 50 ℃; for 24h; Solvent;

upstream raw materials:

2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide

citric acid

2,5-dichlorobenzoyl chloride

2-[(2,5-dichlorobenzoyl)amino]acetic acid

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