10.1248/cpb.51.1413
The research focuses on the design and synthesis of antioxidants as potential anti-inflammatory agents, with a particular emphasis on ebselen and its acyclic derivatives. The purpose of the study was to investigate the ability of these compounds to scavenge free radicals and mimic the glutathione peroxidase (GSH Px)-like effects, which are crucial for preventing oxidative stress and associated diseases such as brain dysfunction, cancer, and cardiovascular disease. The researchers synthesized five ebselen and three acyclic ebselen derivatives and evaluated their GSH Px-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. The conclusions drawn from the study indicated that all tested compounds displayed significant GSH Px-like activity, slightly higher than that of ebselen, and the acyclic allylseleno compound 4c showed five times more potent peroxynitrite scavenging activity than ebselen. Key chemicals used in the process included ebselen, its derivatives, DPPH, peroxynitrite, glutathione (GSH), NADPH, and various reagents for the synthesis and evaluation of the compounds, such as thionyl chloride, substituted arylamines, n-butyllithium, selenium, copper (II) bromide, and methyl iodide or allyl bromide for further functionalization.
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