1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: 1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER
• CAS No.: 622386-08-7
• Molecular Formula: C13H19BrN4O2
• Molecular Weight: 343.223
• Mol file: 622386-08-7.mol

Synonyms:1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER;2-bromo-3-(piperazin-1-yl)pyrazine

Chemical Property of 1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PSA: 58.56000
• LogP: 2.29910

Purity/Quality:

97% ^*data from raw suppliers

TERT-BUTYL4-(5-BROMOPYRAZIN-2-YL)PIPERAZINE-1-CARBOXYLATE >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER

There total 4 articles about 1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-5-dibromopyrazine (23229-26-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 5'-bromo-2,3,5,6-tetrahydro-1,2'-bipyrazinyl-4-carboxylic acid tert-butyl ester (622386-08-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 2h;

Reference yield: 73.4%

tert-butyl 4-(pyrazin-2-yl)piperazine-1-carboxylate (622386-07-6) → 5'-bromo-2,3,5,6-tetrahydro-1,2'-bipyrazinyl-4-carboxylic acid tert-butyl ester (622386-08-7)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃;

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → 5'-bromo-2,3,5,6-tetrahydro-1,2'-bipyrazinyl-4-carboxylic acid tert-butyl ester (622386-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethyl acetate; N,N-dimethyl-formamide; 1,4-dioxane / 72 h / 120 °C

2: N-Bromosuccinimide / dichloromethane / 24 h / 0 °C

With N-Bromosuccinimide; potassium carbonate; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 4-(pyrazin-2-yl)piperazine-1-carboxylate

1-t-Butoxycarbonylpiperazine

2-5-dibromopyrazine

Downstream raw materials:

2-bromo-5-(piperazin-1-yl)pyrazine

tert-butyl 4-(5-aminopyrazin-2-yl)piperazine-1-carboxylate

Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

[5-(5-{4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetic acid