Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

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Chemical Name:Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate
CAS No.:1241898-50-9
Molecular Formula:C₂₀H₂₀BrFN₈O₃
Molecular Weight:519.333
Hs Code.:

Synonyms:Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

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Chemical Property of Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

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Technology Process of Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

There total 4 articles about Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241898-46-3
tert-butyl-4-[5-(2H-tetrazol-5-yl)pyrazin-2-yl]piperazine-1-carboxylate

: 111771-13-2
2-bromo-4-fluorobenzoyl chloride

: 105-36-2
ethyl bromoacetate

: C₂₀H₂₀BrFN₈O₃

: 1241898-50-9
Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

Guidance literature:: tert-butyl-4-[5-(2H-tetrazol-5-yl)pyrazin-2-yl]piperazine-1-carboxylate; ethyl bromoacetate; With triethylamine; In tetrahydrofuran; at 80 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; for 1h;

2-bromo-5-fluorobenzoyl chloride;

Reference yield:

: 622386-08-7
5'-bromo-2,3,5,6-tetrahydro-1,2'-bipyrazinyl-4-carboxylic acid tert-butyl ester

: C₂₀H₂₀BrFN₈O₃

: 1241898-50-9
Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 0.33 h / 150 °C / Microwave; Inert atmosphere

2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 19 h / 130 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 80 °C / Sealed tube

3.2: 1 h

3.3: 18 h / 20 °C

With sodium azide; ammonium chloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 622386-07-6
tert-butyl 4-(pyrazin-2-yl)piperazine-1-carboxylate

: C₂₀H₂₀BrFN₈O₃

: 1241898-50-9
Ethyl [5-(5-{-4-[(2-bromo-5-fluorophenyl)carbonyl]piperazin-1-yl}pyrazin-2-yl)-2H-tetrazol-2-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 24 h / 0 °C

2.1: N,N-dimethyl-formamide / 0.33 h / 150 °C / Microwave; Inert atmosphere

3.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 19 h / 130 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 80 °C / Sealed tube

4.2: 1 h

4.3: 18 h / 20 °C

With N-Bromosuccinimide; sodium azide; ammonium chloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;