1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide
CAS No.:1403332-52-4
Molecular Formula:C₁₈H₁₉N₅O
Molecular Weight:321.382
Hs Code.:
Mol file:1403332-52-4.mol

Synonyms:1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide

There total 4 articles about 1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1403332-50-2
1-tert-butyl-5-[2-(methylsulfanyl)pyrimidin-4-yl]-1H-pyrazole-3-carboxamide

: 98-80-6
phenylboronic acid

: 1403332-52-4
1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: 1-tert-butyl-5-[2-(methylsulfanyl)pyrimidin-4-yl]-1H-pyrazole-3-carboxamide; phenylboronic acid; With copper(I) thiophene-2-carboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 130 ℃; for 1h; Inert atmosphere; microwave irradiation;

With ammonium hydroxide; In water; ethyl acetate;

Reference yield:

: 496863-48-0
1-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone

: 1403332-52-4
1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / tetrahydrofuran / -7 °C / Inert atmosphere

1.2: 2.5 h / -11 - 20 °C

2.1: sodium acetate; acetic acid / ethanol / 2 h / 80 °C

3.1: ammonia / methanol / 6 h / 120 °C / microwave irradiation

4.1: copper(I) thiophene-2-carboxylate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 130 °C / Inert atmosphere; microwave irradiation

With copper(I) thiophene-2-carboxylate; ammonia; sodium acetate; acetic acid; sodium t-butanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 1403333-53-8
ethyl 4-[2-(methylsulfanyl)pyrimidin-4-yl]-2,4-dioxobutanoate

: 1403332-52-4
1-tert-butyl-5-(2-phenylpyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; acetic acid / ethanol / 2 h / 80 °C

2: ammonia / methanol / 6 h / 120 °C / microwave irradiation

3: copper(I) thiophene-2-carboxylate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 130 °C / Inert atmosphere; microwave irradiation

With copper(I) thiophene-2-carboxylate; ammonia; sodium acetate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol;