496863-48-0

Basic information

• Product Name: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)
• Synonyms: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI);1-[2-(Methylthio)-4-pyrimidinyl]ethanone;1-(2-(Methylthio)pyrimidin-4-yl)ethanone;1-[2-(Methylsulfanyl)-4-pyrimidinyl]-1-ethanone;4-Acetyl-2-methylthiopyrimidine;1-(2-Methylsulfanyl-pyriMidin-4-yl)-ethanone;1-[2-(Methylsulfanyl)pyriMidin-4-yl]ethan-1-one;1-[2-(Methylsulfanyl)pyriMidin-4-yl]-1-ethanone
• CAS NO: 496863-48-0
• Molecular Formula: C₇H₈N₂OS
• Molecular Weight: 168.21622
• EINECS: 200-589-5
• Product Categories: ACETYLGROUP
• Mol File: 496863-48-0.mol

Chemical Properties

• Boiling Point: 301℃
• Flash Point: 136℃
• Appearance: /
• Density: 1.23
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.05±0.20(Predicted)
• CAS DataBase Reference: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)(496863-48-0)
• EPA Substance Registry System: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)(496863-48-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 496863-48-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-[2-(methylthio)-4-pyrimidinyl](9CI) is utilized as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Agrochemical Industry:
In the agrochemical sector, Ethanone, 1-[2-(methylthio)-4-pyrimidinyl](9CI) serves as a key component in the formulation of pesticides and other crop protection agents. Its chemical properties allow it to be integrated into products that can effectively control pests and diseases, thereby enhancing crop yield and quality.

InChI:InChI=1/C7H8N2OS/c1-5(10)6-3-4-8-7(9-6)11-2/h3-4H,1-2H3

Upstream product

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• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 521092-40-0 4-(1-ethoxyvinyl)-2-methylsulfanylpyrimidine 
• 521092-35-3 4-(1,1-dimethoxy-ethyl)-2-methylsulfanyl-pyrimidine 

Downstream Products

• 521092-07-9 1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-64-8 C₁₇H₂₁N₃O₄S 
• 521091-13-4 C₁₆H₁₆FN₅O 
• 521087-88-7 1-(2-cyanobenzyl)-3-(4-fluorophenyl)-4-(2-isopropoxypyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-46-6 1-(2-methylsulfanylpyrimidin-4-yl)ethanoneoxime tosylate 
• 521092-16-0 1-(4-fluorophenyl)-5-(2-methylsulfinylpyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-71-7 C₁₆H₁₉FN₄O₃S 
• 521092-72-8 C₁₆H₁₉FN₄O₅S 
• 521092-13-7 1-(2-cyanobenzyl)-3-(4-fluorophenyl)-4-(2-methylsulfinylpyrimidin-4-yl)-4-imidazolin-2-one 
• 1453847-79-4 1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1453852-84-0 1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1453852-82-8 1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1453852-80-6 1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1403332-60-4 N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide 

Relevant articles and documents

AMINOPYRIMIDINE COMPOUND USED FOR INHIBITING ACTIVITY OF PROTEIN KINASE

The present invention relates to an aminopyrimidine compound having an inhibitory effect on the activity of protein kinase as well as the preparation and use thereof. Specifically, disclosed by the present invention is an aminopyrimidine compound represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate or hydrate thereof, as well as a pharmaceutical composition comprising said compound and a use method therefor. The method comprises a method for treating cell proliferative diseases and conditions such as cancer and immune diseases.

PROCESS FOR PRODUCTION OF 4-ACETYLPYRIMIDINES AND CRYSTALS THEREOF

Compound (II) is reacted with formate in the presence of an alkali metal alkoxide and the like to give compound (III); then this is reacted with compound (IVa) or compound (IVb) to give compound (V); then this is reacted with compound (VI) to give compoun

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

4-IMIDAZOLIN-2-ONE COMPOUNDS

The present invention relates to a compound of the formula [I] : ???wherein G1 is an alkyl which,may be substituted by a halogen atom or an alkoxy, or a group of the formula: ??????wherein ring B is benzene ring which may be substituted, etc.,