(7R,12S,18S)-12-methyl-6-methylidene-17-oxa-14-azahexacyclo[10.6.3.15,8.01,11.02,8.014,18]docosan-7-ol

Base Information

Chemical Name:(7R,12S,18S)-12-methyl-6-methylidene-17-oxa-14-azahexacyclo[10.6.3.15,8.01,11.02,8.014,18]docosan-7-ol
CAS No.:76-53-9
Molecular Formula:C₂₂H₃₃NO₂
Molecular Weight:343.51
Hs Code.:
NSC Number:304674

Synonyms:VEATCHINE;NSC304674;NSC-304674;76-53-9;5H,11-Methano-6,13b-propanocyclohept[h]oxazolo[2,3-a]isoquinolin-9-ol, dodecahydro-6-methyl-10-methylene-

Suppliers and Price of (7R,12S,18S)-12-methyl-6-methylidene-17-oxa-14-azahexacyclo[10.6.3.15,8.01,11.02,8.014,18]docosan-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
VEATCHINE 95.00%
5MG
$ 498.34

Total 3 raw suppliers

Chemical Property of (7R,12S,18S)-12-methyl-6-methylidene-17-oxa-14-azahexacyclo[10.6.3.15,8.01,11.02,8.014,18]docosan-7-ol

Chemical Property:

Vapor Pressure:2.55E-11mmHg at 25°C
Melting Point:119-120°
Boiling Point:482.2°Cat760mmHg
Flash Point:245.4°C
PSA：32.70000
Density:1.19g/cm³
LogP:3.51620
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:343.251129295
Heavy Atom Count:25
Complexity:634

Purity/Quality:

99% ^*data from raw suppliers

VEATCHINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCCC3(C1CCC45C3CCC(C4)C(=C)C5O)C6N(C2)CCO6
Isomeric SMILES:C[C@]12CCCC3(C1CCC45C3CCC(C4)C(=C)[C@H]5O)[C@H]6N(C2)CCO6
Description This alkaloid occurs in Garrya species and is a major constituent of G. veatchii. It is laevorotatory with [α]27.5D - 69.01°. The crystalline hydrochloride has m.p. 2Sl-2°C (dec.); hydrobromide, m.p. 229-2300 C and the hydriodide, m.p. 222-3°C (dec.). The O-acetate has m.p. l52-3°C and yields a hydrochloride, m.p. 258-9°C. The structure has been determined by chemical analysis and from spectroscopic data.

Technology Process of (7R,12S,18S)-12-methyl-6-methylidene-17-oxa-14-azahexacyclo[10.6.3.15,8.01,11.02,8.014,18]docosan-7-ol

There total 12 articles about (7R,12S,18S)-12-methyl-6-methylidene-17-oxa-14-azahexacyclo[10.6.3.15,8.01,11.02,8.014,18]docosan-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 75-21-8,99932-75-9
oxirane

: 68831-67-4
lindheimerine

: 76-53-9,509-30-8,11018-10-3,62014-63-5,76984-76-4,21913-33-7,28596-06-7
garryfoline

Guidance literature:: In methanol; at 25 ℃; for 15h;
DOI:10.1021/jo00322a020

Reference yield:

: 68719-14-2,70614-02-7,76984-75-3
ovatine

: 76-53-9,509-30-8,11018-10-3,62014-63-5,76984-76-4,21913-33-7,28596-06-7
garryfoline

Guidance literature:: With potassium carbonate; In methanol; Ambient temperature;
DOI:10.1021/jo00322a020

Reference yield:

: 76946-28-6
garryfoline azomethine

: 76-53-9,509-30-8,11018-10-3,62014-63-5,76984-76-4,21913-33-7,28596-06-7
garryfoline

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / Ambient temperature; overnight

2: 96 percent / methanol / 15 h / 25 °C

In pyridine; methanol;
DOI:10.1021/jo00322a020